Why does linezolid cause lactic acidosis?
Why does linezolid cause lactic acidosis?
Its mechanism of action is inhibiting bacterial protein synthesis by binding to 23S ribosomal RNA in the 50S subunit, preventing fusion with the 30S subunit and formation of the initiation complex. Linezolid-induced lactic acidosis has already been reported, especially after prolonged use (≥28 days).
What can you take for lactic acidosis?
Intravenous administration of sodium bicarbonate has been the mainstay in the treatment of lactic acidosis. Aggressive use of this therapeutic modality, however, can lead to serious complications and should therefore be considered with caution.
Which IV fluid is best for lactic acidosis?
Ringer’s lactate is a versatile IV-fluid choice for resuscitation. Ringer’s lactate is superior to normal saline in many ways; however, at times avoided by clinicians due to the stigma of containing lactate.
Can linezolid cause lactic acidosis?
Linezolid inhibits bacterial growth by targeting bacterial ribosomes and by interfering with bacterial protein synthesis. Lactic acidosis is a rare, but potentially lethal, side effect of linezolid.
How do I know if I have lactic acidosis?
The symptoms of lactic acidosis include abdominal or stomach discomfort, decreased appetite, diarrhea, fast, shallow breathing, a general feeling of discomfort, muscle pain or cramping, and unusual sleepiness, tiredness, or weakness. If you have any symptoms of lactic acidosis, get emergency medical help right away.
How do you know if you have lactic acidosis?
Does linezolid cause lactic acidosis?
Linezolid showed an association with treatment-related lactic acidosis. A longer duration of linezolid use (>6 weeks) was one of the risk factors for metabolic acidosis. We suggest checking serum lactate concentrations regularly, especially in those on long-term use. Linezolid showed an association with treatment-related lactic acidosis.
Can I take Zyvox If I am allergic to linezolid?
You should not use Zyvox if you are allergic to linezolid. Do not use linezolid if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, methylene blue injection, phenelzine, tranylcypromine, and others.
What should I know about Zyvox before taking it?
During your treatment with Zyvox, do not start or stop using any other medications unless your doctor tells you to. You should not use this medicine at is resistant to medication if you have untreated or uncontrolled high blood pressure, a carcinoid tumor, adrenal gland tumor, or a severely overactive thyroid.
How do I know if I have an allergic reaction to Zyvox?
Get emergency medical help if you have signs of an allergic reaction to Zyvox (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
