What are thymidine analog mutations?
What are thymidine analog mutations? Thymidine Analog Mutations (TAMs) TAMs are non-polymorphic mutations selected by the thymidine analogs AZT and d4T. They reduce NRTI susceptibility by facilitating primer unblocking (aka nucleotide excision, pyrophosphorolysis) (87,88,89,90,91,92,93). Is tenofovir a thymidine analogue? However, recent clinical trials have demonstrated that the use of thymidine analogue NRTIs and newer alternative […]