Can neutropenia affect pregnancy?
Can neutropenia affect pregnancy?
In the past, pregnancy has been a major concern for patients with severe chronic neutropenia, considered to increase the susceptibility to infections for women with severe chronic neutropenia.
Which CSF may be prescribed to treat neutropenia?
A drug used under the brand names Neupogen, Zarxio, and Nivestym to treat neutropenia (a lower-than-normal number of white blood cells), prevent infection, and prepare the blood for the collection of certain types of blood cells, and under the brand name Granix to treat neutropenia.
What G-CSF stimulates?
Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.
What is prophylactic G-CSF?
Primary prophylactic G-CSF (PPG) is often used to decrease incidence of FN in patients at high risk. Due to the potential for G-CSF to stimulate neutrophil precursors at the same time as myelosuppression from chemotherapy, it is recommended that G-C SF be administered 24 hours after chemo administration.
What are G-CSF injections?
G-CSF injections are a synthetic version of this naturally occurring growth factor. G-CSF injections are given before you donate your stem cells to boost your white cells and to release stem cells into the bloodstream ready to collect. G-CSF is also given to some patients receiving treatment for cancer.
How quickly does G-CSF work?
This usually takes 5 to 7 days, although it can be longer. Long-acting G-CSF is given as a single injection the day after chemotherapy has completed. If you are having G-CSF before a stem cell transplant, you usually have your first injection 4 to 6 days before your stem cells are going to be collected.
Can you live with cyclic neutropenia?
Individuals with cyclic neutropenia are abnormally susceptible to bacterial infections that often affect the skin, digestive (gastrointestinal) tract, and respiratory system. Such bacterial infections vary in severity and, in some cases, may result in life-threatening complications.
How do you manage cyclic neutropenia?
What are the treatments for cyclic neutropenia (CyN)?
- Antibiotics for infections.
- Granulocyte colony-stimulating factor (G-CSF), filgrastim (Neupogen®)
- Bone marrow transplant. This is rarely needed, but could be done if a person CyN does not respond to available treatments ordevelops cancer.
Is long-term G-CSF effective in the treatment of congenital neutropenia?
These data indicate that congenital, cyclic, and idiopathic neutropenia can be effectively treated with long-term G-CSF. The risk of leukemia, osteoporosis, other potentially adverse events, and pregnancy outcome need to be further evaluated with continuing long-term observations.
How do you treat cyclic neutropenia with granulocyte colony stimulation factor?
Treatment with granulocyte colony-stimulating factor (G-CSF), also called Neupogen, is effective in raising blood neutrophil counts in cyclic neutropenia. G-CSF treatment reduces the symptoms and problems of infections in almost all people.
What is the prognosis of cyclic neutropenia?
The cycling seems to decrease with age and may disappear by age 30 in some patients. Individuals with cyclic neutropenia only have symptoms during times of neutropenia. At other times when their neutrophil levels are normal, they are not at an increased risk for infection and inflammation. [3] [4]
What is the prevalence of myelodysplasia in congenital neutropenia?
As of January 1, 2000, myelodysplasia (MDS) or acute myelogenous leukemia (AML) has occurred in 35 of 387 patients with congenital neutropenia with a cumulative risk of 13% after 8 years of G-CSF treatment. This event occurred without a predictable relationship to the duration or dose of G-CSF treatment.
