What is the therapeutic range for aminophylline?
What is the therapeutic range for aminophylline?
Aminophylline has a narrow therapeutic index, therefore cautious dosage determination is essential. Therapeutic serum concentrations of theophylline are considered to range from 10 to 20 mcg/ml and levels greater than 20 mcg/ml are often associated with toxic effects.
What are normal lab values for theophylline?
The reference therapeutic ranges of theophylline are listed below. Reference ranges of theophylline in the treatment asthma vary by age, as follows: Adults: 5-15 µg/mL. Children: 5-10 µg/mL.
What is aminophylline toxicity?
Aminophylline is a useful but a potentially toxic drug which may cause severe reactions or even death, due usually to overdosage of or possibly hypersensitivity to the drug. 3. The earliest and most constant symptom of toxicity is restlessness. The next important and almost constant symptom is frequent vomiting.
When should aminophylline levels be checked?
Take aminophylline level 4-6 hours after maintenance infusion starts, pausing infusion 20 minutes prior to taking level. Do not adjust the dose/frequency if first level is between 8-10mg/L. Re-check level after a further 24 hours. Monitor aminophylline levels daily if infusion continues for more than 24 hours.
What is the antidote for aminophylline?
Intravenous aminophylline: morphine as antidote to poisoning.
Can aminophylline cause hypotension?
Both compounds produced a dose-dependent hypotension. Aminophylline frequently caused bradycardia in intact dogs and positive chrono- and inotropic effects in isolated atria.
Who should not take aminophylline?
Do not take aminophylline without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from aminophylline. You may require a lower dose of this medication.
What is a common side effect of aminophylline?
increased or rapid heart rate. irregular heartbeat. seizures. skin rash.
How often should I Check my aminophylline levels?
Intravenous Aminophylline Dose Titration 25 to 30 with risk of further reaction >30 mg/ Check Plasma Theophylline Level within 4-6 hours of commencement Re-Check Plasma Theophylline Level after any dose adjustment, within 4-6 hours. Check Plasma Theophylline Level every 24 hours, even if levels stable.
How stable is aminophylline in parenteral solution?
Aminophylline injections reportedly are not stable in soln having a pH substantially less than 8; however, the drug appears to be relatively stable in large volume parenteral soln over a wide pH range (3.5-8.6) if aminophylline concn do not exceed 40 mg (31.6 mg of anhydrous theophylline) per mL.
How long does aminophylline stay in your system?
Theophylline clearance rates and half-life values were measured in 15 infants aged three to 23 months, after infusion of aminophylline by the intravenous route for at least 24 hours. The mean half-life was 4.4 +/- 2.2 hours.
What is aminophylline made of?
Aminophylline is a mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. It has a role as a bronchodilator agent and a cardiotonic drug. It contains a theophylline and an ethylenediamine. Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio.
