What is Triclabendazole used for?
What is Triclabendazole used for?
Triclabendazole is used to treat fascioliasis, an infection caused by the liver fluke parasite, Fasciola hepatica.
Which parasites does ivermectin treat?
Ivermectin (/ˌaɪvərˈmɛktɪn/, EYE-vər-MEK-tin) is an antiparasitic medication. Parasitic infestations in humans include head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis.
How do you take Triclabendazole?
Triclabendazole comes as a tablet to take by mouth. It is usually taken every twelve hours for 2 doses. Take triclabendazole with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Is Triclabendazole safe in pregnancy?
Triclabendazole Pregnancy and Breastfeeding Warnings The manufacturer makes no recommendation regarding use during pregnancy.
Is Triclabendazole available in the US?
The FDA has approved triclabendazole (Egaten) for the treatment of fascioliasis, a neglected tropical disease in patients 6 years of age and older.
What are the symptoms of intestinal flukes?
With heavy infections Fasciolopsis flukes can cause intestinal obstruction, abdominal pain, nausea, vomiting, and fever. Allergic reactions and swelling of the face and legs can also occur — and anemia may be present.
Is triclabendazole an anthelmintic?
Benzimidazole anthelmintics The benzimidazole derivatives albendazole, flubendazole, mebendazole, thiabendazole, and triclabendazole inhibit the uptake of glucose and thereby kill the parasites.
What is the mechanism of action of triclabendazole against Fasciola hepatica adults?
Similar to other benzimidazoles, the mechanism of action of triclabendazole results from inhibition of microtubule formation. The β-tubulin protein of Fasciola hepatica exhibits species-specific protein changes at position 82 (glutamic acid) and position 91 (threonine), which are unique among nematodes and cestodes.
What is the treatment for liver flukes?
It’s possible to eradicate liver flukes completely. An infection will usually be treated with a drug called triclabendazole. It’s given orally, usually in one or two doses, and most people respond well to this treatment. A short course of corticosteroids is sometimes prescribed for acute phases with severe symptoms.
