Can present antigens on MHC II?
Can present antigens on MHC II?
Antigen presentation is mediated by MHC class I molecules, and the class II molecules found on the surface of antigen-presenting cells (APCs) and certain other cells. Endogenous antigens can also be presented by MHC class II when they are degraded through autophagy.
What is the main difference between the action of MHC class 1 and MHC Class 2?
The main difference between MHC class 1 and 2 is that MHC class 1 molecules present antigens to cytotoxic T cells with CD8+ receptors whereas MHC class 2 molecules present antigens to helper T cells with CD4+ receptors.
What are MHC 2 antigens?
MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.
How are antigens presented by MHC?
In the classical MHC class II presentation pathway, exogenous antigens are acquired by antigen-presenting cells and delivered into the endo-lysosomal system, where they are broken down to peptides and presented on MHC class II molecules.
What would be an appropriate response if an antigen is presented on MHC class II molecules?
The process in which a lymphocyte’s antigen receptor binds to an antigen, allowing the lymphocyte to multiply. What would be an appropriate response if an antigen is presented on MHC class II molecules? An effector CD4 cell activates the presenting cell.
What is the source of peptides presented on MHC class I molecules and MHC class II molecules?
MHC I molecules present peptides from the proteins that are synthesized by cells. In healthy cells, all of these proteins are autologous ones to which CD8+ T cells are tolerant.
What do MHC II markers do?
Antigen presentation with MHC II is essential for the activation of T cells. Antigen-presenting cells (APCs) primarily ingest pathogens by phagocytosis, destroy them in the phagolysosomes, process the protein antigens, and select the most antigenic/immunodominant epitopes with MHC II for presentation to T cells.
Does the MHC class II antigen presentation pathway differ by subset?
The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines PLoS One. 2017 Aug 23;12(8):e0183594.doi: 10.1371/journal.pone.0183594. eCollection 2017. Authors
Which intermediate monocytes express the highest levels of MHC molecules?
In this study, we investigated the expression patterns of MHC class II (MHCII) and associated molecules and find that the intermediate monocytes express the highest levels of the MHC molecules, HLA-DR (tested in n = 30 samples), HLA-DP (n = 30), and HLA-DQ (n = 10).
Are intermediate monocytes the most efficient constitutive antigen presenting subsets?
All three subsets decrease HLA-DR levels after IL-10 exposure. Our findings argue that intermediate monocytes are the most efficient constitutive antigen presenting subset, that classical monocytes are recruited into an antigen presentation role during inflammatory responses and that IL-10 negatively regulates this function across all subsets.
