How is rabies replicated?
How is rabies replicated?
The replication of rabies virus is believed to be similar to that of other negative-stranded RNA viruses. The virus attaches to the host cell membranes via the G protein, penetrates the cytoplasm by fusion or pinocytosis, and is uncoated to RNP.
Is rabies prokaryote or eukaryote?
Viruses are neither prokaryotic or eukaryotic. Viruses are not made of cells.
Where does rabies replication occur?
Rabies virus first replicates in striated muscle tissue at the site of inoculation. It then enters the peripheral nervous system at the neuromuscular junctions and spreads up the nerves to the central nervous system, where it replicates exclusively within the gray matter.
How are rabies caused?
The rabies virus causes a rabies infection. The virus spreads through the saliva of infected animals. Infected animals can spread the virus by biting another animal or a person. In rare cases, rabies can be spread when infected saliva gets into an open wound or the mucous membranes, such as the mouth or eyes.
Is E coli a prokaryote?
coli: A Model Prokaryote. Much of what is known about prokaryotic chromosome structure was derived from studies of Escherichia coli, a bacterium that lives in the human colon and is commonly used in laboratory cloning experiments.
Why does rabies cause hydrophobia?
People used to call rabies hydrophobia because it appears to cause a fear of water. The reason is that the infection causes intense spasms in the throat when a person tries to swallow. Even the thought of swallowing water can cause spasms, making it appear that the individual is afraid of water.
What are the final stages of rabies in humans?
As the disease progresses, the person may experience delirium, abnormal behavior, hallucinations, hydrophobia (fear of water), and insomnia. The acute period of disease typically ends after 2 to 10 days. Once clinical signs of rabies appear, the disease is nearly always fatal, and treatment is typically supportive.
What is the replication of rabies virus?
The replication of rabies virus is believed to be similar to that of other negative-stranded RNA viruses. The virus attaches to the host cell membranes via the G protein, penetrates the cytoplasm by fusion or pinocytosis, and is uncoated to RNP.
How does the rabies virus enter the cell membrane?
It results in fusion of the rabies virus envelope with the host cell membrane. After adsorption, the virus penetrates the host cell and enters the cytoplasm by pinocytosis through clathrin-coated pits. The virions aggregate in the large endosomes i.e. cytoplasmic vesicles.
What is the mode of reproduction in E coli?
This is the most prevalent form of reproduction for E. coli. The individual bacterium begins this process by elongation of the cell, followed by almost exact replication of the genome so there are two identical copies. Mutations and mistakes may happen during genetic replication, but normally these occur in small numbers…
What is the pathophysiology of rabies?
Pathogenesis After inoculation, rabies virus may enter the peripheral nervous system directly and migrates to the brain or may replicate in muscle tissue, remaining sequestered at or near the entry site during incubation, prior to central nervous system invasion and replication. It then spreads centrifugally to numerous other organs.
https://www.youtube.com/watch?v=Jo_XU0HTkLU
