What is the pH of Oxindole?
What is the pH of Oxindole?
Oxindole has a solubility of approximately 0.5 mg/ml in a 1:1 solution of ethanol:PBS (pH 7.2) using this method.
Is Oxindole aromatic?
Oxindole (2-indolone) is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing ring.
Is Oxindole polar?
7-(2′-Pyridyl)indole is practically nonfluorescent at room temperature, in nonpolar and polar aprotic solvents.
What is the systematic name for indole?
Indole is an aromatic heterocyclic organic compound with formula C8H7N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring….Indole.
| Names | |
|---|---|
| Preferred IUPAC name 1H-Indole | |
| Other names 2,3-Benzopyrrole, ketole, 1-benzazole | |
| Identifiers | |
| CAS Number | 120-72-9 |
What is the structure of indole?
C8H7N
Indole/Formula
What is indole used for in bacteria?
Indole is an intercellular signal in both gram-positive and gram-negative bacteria and has been shown to control a number of bacterial processes such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence (Lee & Lee, 2010).
Is indole an acid?
Basicity. Unlike most amines, indole is not basic: just like pyrrole, the aromatic character of the ring means that the lone pair of electrons on the nitrogen atom is not available for protonation. Strong acids such as hydrochloric acid can, however, protonate indole.
Is indole an enzyme?
The indole test is a biochemical test performed on bacterial species to determine the ability of the organism to convert tryptophan into indole. This division is performed by a chain of a number of different intracellular enzymes, a system generally referred to as “tryptophanase.”
What bacteria produces indole?
many pathogenic bacteria such as Bacillus alvei, pathogenic E. coli, several Shigella strains, Enterococcus faecalis, and V. cholerae, can produce indole.
Is indole a gas?
Indole is a solid at room temperature.
What is oxindole made of?
Oxindole is a modified indoline with a substituted carbonyl at the second position of the 5-member indoline ring. Oxindole is a tryptophan derivative and in human biology is formed by gut bacteria (“normal flora”). It is normally metabolized and detoxified from the body by the liver.
What are oxoxindole alkaloids?
Oxindole alkaloids are a monoterpene group of alkaloids derived from the amino acid tryptophan, that exhibits an oxindole moiety (N–C O) in ring B ( Fig. 1 ). These alkaloids are typically found to co-occur with their corresponding corynantheoid or ajmalicinoid analogues [42].
What is the role of oxindole in Medicinal Chemistry?
Oxindole has shown invaluable potential as an important scaffold in medicinal chemistry, possessing a diverse range of pharmacological activities. Traditional as well as present emerging therapeutic potential of oxindole nucleus has encouraged the medicinal chemists to synthesize novel oxindole derivatives.
Why use oxindole for multitargeting molecules?
Maninder Kaur, in Key Heterocycle Cores for Designing Multitargeting Molecules, 2018 Oxindole has shown invaluable potential as an important scaffold in medicinal chemistry, possessing a diverse range of pharmacological activities.
