What is detomidine used for in horses?

What is detomidine used for in horses?

Detomidine is used primarily as a sedative, anesthetic adjunct, and analgesia. It is used in horses more often than in other species. When used to treat pain from colic in horses, the duration of effect is approximately 3 hours (20 or 40 mcg/kg). Detomidine also has been administered for epidural analgesia.

What drug class is detomidine?

Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan.

What is the difference between Medetomidine and detomidine?

Medetomidine Hydrochloride Medetomidine, dexmedetomidine, and detomidine are more specific for the alpha2 receptor than xylazine. Dexmedetomidine has twice the potency of medetomidine. Therefore these drugs should not be used interchangeably without consulting the dose recommendations.

Is detomidine a controlled substance?

“Detomidine hydrochloride is not a controlled substance like butor- phanol tartrate used in combination with other molecules,” said Dr. Donecker. “By using Dormosedan as a simple, one-sedative variable the veterinarian has more control over the level of sedation and analgesia.

What is the reversal agent for detomidine?

Conclusions and potential relevance: Single bolus administration of atipamezole or tolazoline produced partial reversal of detomidine sedation and may be useful for minimising detomidine sedation.

What is detomidine HCL?

How long does horse sedation last?

As a general rule, the effects of sedation end about an hour after the drug is administered. The timing depends on many factors, however, and some horses will “come around” after 30 minutes, while other remain stupefied for an hour and a half.

What happens if you give Antisedan IV?

Atipamezole administered IV may result in rapid relaxation of vascular tone, which coupled with bradycardia could result in cardiovascular collapse.

Can Xylazine be given IM in horses?

Xylazine administered intramuscularly (IM) to horses at the dose level of 2 mg/kg was an effective sedative and preanesthetic for thiamylal sodium narcosis or thiamylal sodium and halothane anesthesia.

How long does Antisedan last?

The effects of atipamezole typically last two to three hours, which can be significantly shorter than the agents it is reversing; therefore, multiple doses may be indicated based on clinical signs that the animal is exhibiting (especially recurrence of significant cardiovascular signs).

What is detdetomidine gel for horses used for?

Detomidine in the gel form (Dormosedan Gel) for horses is administered orally to produce mucosal absorption. It is indicated for producing minor standing sedation to facilitate minor procedures (shoeing, clipping, trimming) or calming a fractious horse.

How much Detomidine is needed to sedate a cow?

The doses of detomidine required in cattle appear to be similar to those in horses. Again, early experimental work suggested that high doses were needed for adequate sedation but subsequent trials have shown that doses of up to 30 mg/kg are satisfactory.

Is detomidine in Dormosedan?

Dormosedan injection (containing detomidine) has been used for more than 20 years worldwide, now a new formulation gel is available. Dormosedan Gel contains the same drug – detomidine – that is commonly given by intravenous injection for sedation of even the most factious animals.

What is Dormosedan gel for horses used for?

DORMOSEDAN GEL ® (detomidine hydrochloride) is a safe and effective mild standing sedative for use prior to routine horse care procedures. On occasions when your horse becomes nervous, frightened or won’t cooperate, DORMOSEDAN GEL can help restore safety for you and your horse.