How do you administer cladribine?
How do you administer cladribine?
Cladribine is administered by infusion through a vein. The infusion may be over 1-2 hours on consecutive days, or may be a continuous infusion over several days. The way it is given depends on the protocol chosen by your physician. There is no pill form of cladribine.
What is cladribine intravenous?
Descriptions. Cladribine belongs to the group of medicines called antimetabolites. It is used to treat hairy cell leukemia, a cancer of the blood and bone marrow. It is also sometimes used to treat other kinds of cancer, as determined by your doctor.
Why does cladribine need to be filtered?
In order to minimize the risk of microbial contamination, both LEUSTATIN Injection and the diluent should be passed through a sterile 0.22µ disposable hydrophilic syringe filter as each solution is being introduced into the infusion reservoir.
Is cladribine a chemotherapy?
Cladribine is one of a group of chemotherapy drugs known as anti metabolites. These stop cells making and repairing DNA. Cancer cells need to make and repair DNA so that they can grow and multiply. Cladribine kills abnormal white blood cells.
Is hair loss an MS symptom?
Hair loss is not a symptom of MS, but could be related as a side effect of a medication, or due to the stress of an MS diagnosis. The majority of hair loss or thinning is temporary, and does not require treatment.
Does cladribine inhibit adenosine deaminase?
Cladribine does not inhibit adenosine deaminase (68). The MOA by which cladribine induces apoptosis is not settled, and it is likely to have more than one component. The drug may become incorporated into DNA and inhibit the ongoing “housekeeping” activity of DNA repair, or it may directly inhibit DNA polymerases (69).
Does MS cause weight gain?
Exercise is beneficial for people with MS, whether they want to lose or gain weight. Though gaining weight is more common with MS, weight loss and muscle wasting can occur in advanced and serious cases. People who experience muscle loss usually have symptoms that are severe enough to limit mobility.
