What drugs are antitumor agents?
What drugs are antitumor agents?
Doxorubicin, mitoxantrone, and bleomycin are some examples of antitumor antibiotics. One of the most important decisions for the oncologist is prescribing the right amount of anti-cancer drugs. Although large doses will kill more cells, greater amounts of drugs will produce more severe side effects.
Which drug is an Alkylator?
An antineoplastic agent used to treat Hodgkin’s disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia. An alkylating agent used to treat chronic myelogenous leukemia….Alkylating Drugs.
| Drug | Target | Type |
|---|---|---|
| Carmustine | RNA | target |
| Chlorambucil | DNA | target |
| Chlorambucil | Glutathione S-transferase P | enzyme |
Which drug is not an alkylating agent?
Note: Although the platinum-containing anticancer agents, carboplatin, cisplatin, and oxaliplatin are frequently classified as alkylating agents, they are not.
What is the antitumor?
Listen to pronunciation. (AN-tee-TOO-mer) Having to do with stopping abnormal cell growth.
How is chemotherapy related to chemistry?
Chemotherapy is the use of chemical substances to treat disease. In its modern-day use, it refers primarily to cytotoxic drugs used to treat cancer. Cancer is the uncontrolled growth of cells due to damage to DNA (mutations) and, occasionally, due to an inherited propensity to develop certain tumours.
What do chemotherapy agents do?
Chemotherapy drugs help destroy, shrink, or control those cells. It might also treat symptoms the cancer causes, like pain. You might also get chemo to shrink a tumor before your doctor removes it in surgery.
How do alkylating agents?
How do alkylating agents work? Alkylating agents work by destroying the DNA in cancer cells. This is done by replacing alkyl groups with hydrogen atoms in the DNA so the cells can’t repair themselves. As a result, the lack of functioning DNA prevents cancer cell division and replication.
Do epipodophyllotoxins cause Secondary leukaemia after childhood cancer?
Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer Epipodophyllotoxins acting alone or together with alkylating agents or radiation seem to be involved in secondary leukaemia after childhood cancer.
What is the mode of action of alkylating drugs?
The primary mode of action for most alkylating drugs is via cross-linking of DNA strands. They can be classified as either monofunctional alkylating agents, implying reactions with only one strand of DNA, or bifunctional alkylating agents, which cross-link two strands of DNA.
What are the sources of alkylating agents?
Alkylating agents comprise a diverse group of chemical compounds, and sources include industrial chemicals, environmental contaminants, naturally occurring compounds, chemotherapeutic drugs, and experimental carcinogens.
Do alkylating agents cause alopecia?
Alkylating agents cause alopecia and have immunosuppressive effects Chabner et al (2001), Pratt et al (1994), Tew et al (2001), Fraiser et al (1991). Alkylating agents (ATC code L01A) are highly reactive compounds that easily attach to DNA and cellular proteins.
