Is simvastatin good for kidneys?
Is simvastatin good for kidneys?
Use of statins is beneficial for most patients with CKD who are at high cardiovascular risk [7], although research is needed to ascertain how to best prevent kidney injury. Experimental evidence suggests that statin can prevent the progression of kidney injury [3].
Does simvastatin raise creatinine levels?
Unadjusted serum creatinine concentrations increased for all patients, with or without diabetes, over a period of 4.6 years; however, allocation to simvastatin significantly reduced the rise in serum creatinine in both cohorts.
Do statins cause renal toxicity?
Recent reports indicate that statins can cause nephrotoxicity. However, the mechanisms of nephrotoxicity remain unclear. We report a case of acute kidney injury (AKI) in a 54-year-old man following the administration of atorvastatin Renal biopsy showed acute interstitial nephritis.
Is simvastatin hard on kidneys?
TUESDAY, March 19 (HealthDay News) — People who take high doses of popular cholesterol-lowering drugs called statins may be more likely to develop kidney problems, a new study suggests.
Can statins reduce kidney function?
In the pairwise meta-analysis we showed that use of statins lowered the rate of annual kidney function decline by 0.61 mL/min/1.73 m2 and reduced the amount of proteinuria by −0.58 (95%-CI −0.88; −0.29) standard deviations per year.
Which statin is best for kidneys?
However, they pooled for each statin all dosages. The validity of these comparisons may be limited, considering the clear differential effects of different dosages8,66. We showed that fluvastatin 20 mg/ezetimibe 10 mg was the most efficacious treatment regarding both renal outcomes.
Is 80 mg of simvastatin a lot?
[06-08-2011] The U.S. Food and Drug Administration (FDA) is recommending limiting the use of the highest approved dose of the cholesterol-lowering medication, simvastatin (80 mg) because of increased risk of muscle damage.
Does simvastatin affect the kidneys?
Simvastatin is used in adults and children who are at least 10 years old. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure.
Which drugs are harmful to your kidneys?
NSAIDS. NSAIDS,or nonsteroidal anti-inflammatory drugs like ibuprofen (Advil,Motrin) and naproxen (Aleve),lead the list for drugs that cause kidney damage because of their widespread use.
Do statins harm kidneys?
Use of high-dose statins is associated with an increased risk of diagnosis for acute kidney injury compared with low potency statins, the researchers say, with the effect strongest in the first 120 days of treatment.
What medications can you take with kidney disease?
– Cholesterol medications. The dosing of certain cholesterol medications, known as “statins”, may need to be adjusted if you have chronic kidney disease. – Pain medications. – Anti-microbial meds. – Diabetes medications. – Upset stomach/antacid medications.
