What is G-CSF in medical terms?

What is G-CSF in medical terms?

A drug used under the brand names Neupogen, Zarxio, and Nivestym to treat neutropenia (a lower-than-normal number of white blood cells), prevent infection, and prepare the blood for the collection of certain types of blood cells, and under the brand name Granix to treat neutropenia.

What is the role of G-CSF?

G-CSF stimulates the BM to produce granulocytes and stem cells and release them into the bloodstream. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways.

What is G-CSF in immunology?

Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine playing a major role as regulator of hematopoiesis and innate immune responses. G-CSF mediates anti-inflammatory reactions accompanied by TH2 cell differentiation and promotes tolerogeneic cell populations at both poles of APC/T cell interaction.

How is G-CSF administered?

Filgrastim may be given subcutaneous (the layer between the skin and muscle) injection or infused into a vein (intravenous, IV). Filgrastim is generally given on a daily basis. The number of days you receive filgrastim will be prescribed by your doctor.

Can G-CSF cause fever?

G-CSF causes low-grade fever that is ameliorated by nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting the activation of arachidonic acid (AA) cascade. How G-CSF regulated this reaction was assessed.

What is G-CSF primed bone marrow?

Granulocyte–colony-stimulating factor (G-CSF)–primed allogeneic bone marrow: significantly less graft-versus-host disease and comparable engraftment to G-CSF–mobilized peripheral blood stem cells. From the Bone Marrow Transplant Unit, Royal Brisbane Hospital, Herston, Australia.

Can G-CSF cause leukemia?

G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.

What cells produce G-CSF?

Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).

When is filgrastim given?

It is usually given once a day, but filgrastim injection products (Neupogen, Nivestym, Zarxio) may be given twice a day when it is used to treat severe chronic neutropenia. The length of your treatment depends on the condition that you have and how well your body responds to the medication.

Is G-CSF injection painful?

The most relevant adverse event of G-CSF administration is bone pain. Approximately 20% of cancer patients experienced bone pain with the administration of prophylactic daily G-CSFs (lenograstim and filgrastim).

What does G-CSF mean in medical?

We found 17 meanings of G-CSF abbreviation related to Medical: Granulocyte Colony Stimulating Factor + 11 variants Granulocyte colony stimulating factor promotes production of white blood cells Granulocyte-macrophage colony-stimulating factor Granulocyte colony-stimulating growth factor

What is granulocyte colony stimulating factor G-CSF?

Granulocyte colony stimulating factor (G-CSF) G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant.

What is pegylated G-CSF and how is it used?

G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant. Pegylated G-CSF stays in the body for longer so you have treatment less often than with the other types of G-CSF.

What is the role of G-CSF in stem cell therapy?

G-CSF also makes some stem cells move from the bone marrow into the blood. Stem cells are very early cells that develop into red blood cells, white cells and platelets.