How is methyl salicylate prepared?
How is methyl salicylate prepared?
Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or wintergreen).
How is methyl salicylate purified?
Esterification is a common method of preparing esters. You will use this method to prepare methyl salicylate from salicylic acid. You will use the technique of vacuum distillation to purify the product.
How is methyl salicylate metabolized?
Minor metabolism may occur in various tissues but hepatic metabolism constitutes the majority of metabolic processes of absorbed methyl salicylate. It is mainly hydrolyzed to salicylic acid via hepatic esterase enzymes.
What functional group is methyl salicylate?
ester
The difference in the two structures is a single functional group. In methyl salicylate (on the left) the benzene ring is substituted by two functional groups, a hydroxyl group (-OH) and an ester group (-COOCH3). In salicylic acid (on the right), the ester group has been replaced by a carboxylic acid group (-COOH).
How is methyl salicylate prepared qualitatively?
Take a mixture of 28 g (0.2 mol) of salicylic acid, 64 g (81 ml, 2 mol) of dry methanol and 8 ml of concentrated sulphuric acid in a round bottomed flask of 500 ml. Put a few small chips of porous porcelain, set a reflux condenser to the flask and boil the mixture gently for 5 h.
What are the functional groups in methyl salicylate?
In methyl salicylate (on the left) the benzene ring is substituted by two functional groups, a hydroxyl group (-OH) and an ester group (-COOCH3).
What is the formula of ch3oh?
CH3OHMethanol / Formula
What is the clinical indication of methyl salicylate?
Methyl salicylate is used as a topical preparation for the skin for temporary relief of muscle pain or joint pain caused by sprains, strains, arthritis, backaches or bruising.
What is synthesis of methyl salicylate?
Synthesis of methyl salicylate. BACKGROUND. Principle: Methyl salicylate (oil of wintergreen) is an organic ester. When an acid (containing the –COOH group) reacts with an alcohol (a compound containing an –OH group) formed an ester.
What is the peak number of methyl salicylate in this experiment?
The peak corresponding to 10.79 ppm corresponds to hydroxyl group; the peak in 6 – 8 ppm range correspond to hydrogen at the aryl ring and peak at 3.92 ppm belongs to the three hydrogen atoms at the alkyl group. Thus, these two analyses confirm synthesis of methyl salicylate in this experiment.
Is methyl salicylate an ester or an acid?
Methyl salicylate (oil of wintergreen) is an organic ester. When an acid (containing the –COOH group) reacts with an alcohol (a compound containing an –OH group) formed an ester.
How do you filter methyl salicylate solution?
Filter the methyl salicylate solution through a small fluted filter paper directly into a round bottomed flask fitted with a still-head carrying a 360 °C thermometer and an air condenser.
