What does it mean if your beta-2 microglobulin is high?

What does it mean if your beta-2 microglobulin is high?

People with cancers of the bone marrow and blood often have high levels of B2M in their blood or urine. These cancers include multiple myeloma, lymphoma, and leukemia. High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.

What is B2M protein?

B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral.

What is the function of beta-2 microglobulin in MHC 1?

β2 microglobulin (B2M) is a small protein that occurs as a monomer in relatively low concentration in biological fluids (1,8 mg/L). It is a component of MHC class I molecules, which are present on all nucleated cells, and that are involved in self-recognition and in defense against micro-organisms.

What is beta-2 microglobulin amyloidosis?

Beta-2 ̶ microglobulin (beta-2m) amyloidosis is a disabling condition that affects patients undergoing long-term hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). Case reports involving patients with near ̶ end-stage renal disease also exist.

What is the role of beta 2 microglobulin?

Impaired renal function and hyperproduction of beta 2-microglobulin are both associated with increased serum levels. A function for beta 2-microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune system is proposed.

Is beta globulin the same as Beta 2 microglobulin?

Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins. Examples of beta globulins include: beta-2 microglobulin.

What is the molecular weight of beta 2 microglobulin?

11,000
Beta2-microglobulin (beta2-MG) with a molecular weight of 11,000 is considered representative of these middle molecules.

What is senile heart?

Senile amyloidosis (SSA) is an underrecognised cause of heart failure in the elderly. It is significantly more common in men. SSA should be considered in elderly men (usually over 70 years of age) with thick walled hearts and on echo and clinical features of heart failure.

What is beta 2 microglobulin B2M?

Beta-2 microglobulin From Wikipedia, the free encyclopedia β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excludes red blood cells). In humans, the β 2 microglobulin protein is encoded by the B2M gene.

What is a beta-2 microglobulin tumor marker test?

What is a beta-2 microglobulin tumor marker test? This test measures the amount of a protein called beta-2 microglobulin (B2M) in the blood, urine, or cerebrospinal fluid (CSF). B2M is a type of tumor marker. Tumor markers are substances made by cancer cells or by normal cells in response to cancer in the body.

What is the difference between α3 and β2 microglobulin?

β 2 microglobulin lies beside the α 3 chain on the cell surface. Unlike α 3, β 2 has no transmembrane region. Directly above β 2 (that is, further away from the cell) lies the α 1 chain, which itself is next to the α 2 .

What is the function of beta 2 microglobulin in cytomegalovirus?

In cytomegalovirus infection, a viral protein binds to β 2 microglobulin, preventing assembly of MHC class I molecules and their transport to the plasma membrane. Mice models deficient for the β 2 microglobulin gene have been engineered.