What is the drug classification of captopril?
What is the drug classification of captopril?
ACE inhibitor
Captopril/Classification
What is the meaning of captopril?
Definition of captopril : an antihypertensive drug C9H15NO3S that is an ACE inhibitor.
What is captopril and how does it work?
Captopril works by blocking a substance in the body that causes blood vessels to tighten. As a result, the blood vessels relax. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Captopril is also used to help treat heart failure.
What is the trade name of captopril?
Captopril is an angiotensin converting enzyme (ACE) inhibitor prescribed for treating high blood pressure, heart failure, and for preventing kidney failure due to high blood pressure and diabetes. Captopril is available under the following different brand names: Capoten and Captoril.
Can captopril be given IV?
The rapid response to intravenous captopril indicates that it may be useful in the treatment of patients with severe heart failure who require intensive treatment.
What do ACE inhibitors do?
Angiotensin-converting enzyme (ACE) inhibitors are medications that help relax the veins and arteries to lower blood pressure. ACE inhibitors prevent an enzyme in the body from producing angiotensin II, a substance that narrows blood vessels.
Is captopril a diuretic?
Captopril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide is a “water pill” (diuretic). This drug increases the amount of urine you make, causing your body to get rid of extra salt and water.
How do ACE inhibitors work?
ACE inhibitors prevent an enzyme in the body from producing angiotensin II, a substance that narrows blood vessels. This narrowing can cause high blood pressure and forces the heart to work harder. Angiotensin II also releases hormones that raise blood pressure.
Is captopril a vasodilator?
Captopril’s main uses are based on its vasodilation and inhibition of some renal function activities. These benefits are most clearly seen in: Hypertension. Cardiac conditions such as congestive heart failure and after myocardial infarction.
Who makes captopril?
Captopril, an analog of the snake venom’s ACE-inhibiting peptide, was first synthesized in 1975 by three researchers at the U.S. drug company E.R. Squibb & Sons Pharmaceuticals (now Bristol-Myers Squibb): Miguel Ondetti, Bernard Rubin, and David Cushman.
How do you administer captopril?
Captopril comes as a tablet to take by mouth. It is usually taken two or three times a day on an empty stomach, 1 hour before a meal. To help you remember to take captopril, take it around the same time(s) every day.
How do ACE drugs work?
Angiotensin-converting enzyme (ACE) inhibitors work by primarily relaxing the blood vessels and thereby bringing down the elevated blood pressure. They are a class of medicines that are used to treat high blood pressure, heart problems, and other conditions.
Is captopril soluble in water?
Captopril is a white to off-white crystalline powder that may have a slight sulfurous odor; it is soluble in water (approx. 160 mg/mL), methanol, and ethanol and sparingly soluble in chloroform and ethyl acetate. CAPOTEN is available in potencies of 12.5 mg, 25 mg, 50 mg, and 100 mg as scored tablets for oral administration.
How long does captopril stay in your system?
Approximately 25 to 30 percent of the circulating drug is bound to plasma proteins. The apparent elimination half-life for total radioactivity in blood is probably less than 3 hours. An accurate determination of half-life of unchanged captopril is not, at present, possible, but it is probably less than 2 hours.
What is the chemical name for captoten?
CAPOTEN is designated chemically as 1-[(2S)-3-mercapto-2-methylpropionyl]-Lproline [MW 217.29] and has the following structure: Captopril is a white to off-white crystalline powder that may have a slight sulfurous odor; it is soluble in water (approx. 160 mg/mL), methanol, and ethanol and sparingly soluble in chloroform and ethyl acetate.
How do you take hydrochlorothiazide and captopril together?
If combination therapy is initiated with captopril/hydrochlorothiazide fixed-combination preparation, initial dosage of captopril 25 mg and hydrochlorothiazide 15 mg once daily; adjust dosage (generally at 6-week intervals) by administering each drug separately or by advancing the fixed-combination preparation.
