Where is galectin 1 found?
Where is galectin 1 found?
The galectin-1 protein is 135 amino acids in length and highly conserved across species. It can be found in the nucleus, the cytoplasm, the cell surface and in the extracellular space. Galectins in general lack a traditional signal sequence, but are still secreted across the plasma membrane.
Is galectin 3 a protein?
Human galectin-3 is a 35-kDa protein that is coded by a single gene, LGALS3, located on chromosome 14. The N-terminal domain of galectin-3 is essential for its multimerization, sensitive to proteolysis by matrix metalloproteinases and may participate in the interaction with other intracellular proteins (3).
What kind of proteins are galectins in humans?
Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation.
How do galectins work?
To date, these galectins bind a panel of receptors on T cells which inhibit the functions of T cells (Table 1). Thus, tumor cell-derived galectins may not only regulate the growth of tumor cells but also dampen T cell responses.
What is the LGALS3 gene?
LGALS3 (Galectin 3) is a Protein Coding gene. Diseases associated with LGALS3 include Follicular Adenoma and Papillary Carcinoma . Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Innate Immune System .
What does LGALS1 stand for?
GeneCards Summary for LGALS1 Gene LGALS1 (Galectin 1) is a Protein Coding gene. Diseases associated with LGALS1 include Trophoblastic Neoplasm and Fucosidosis. Among its related pathways are NF-kappaB Signaling and Apoptosis and Autophagy.
What is LGALS3 (galectin 3)?
Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] LGALS3 (Galectin 3) is a Protein Coding gene. Diseases associated with LGALS3 include Follicular Adenoma and Papillary Carcinoma .
What does the galectin gene do?
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing.
