What is APMPPE eye disease?

What is APMPPE eye disease?

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare eye disorder of unknown (idiopathic) cause. The disorder is characterized by the impairment of central vision in one eye (unilateral) but, within a few days, the second eye may also become affected (bilateral).

Is Apmppe an autoimmune disease?

The syndrome of APMPPE has also been associated with other systemic autoimmune diseases such as necrotizing vasculitis,21 Wegener granulomatosis,22 cerebral vasculitis,23 polyarteritis nodosa,24 and ulcerative colitis.

What is Pachychoroid pigment Epitheliopathy?

A unique entity termed pachychoroid pigment epitheliopathy characterized by reduced fundus tessellation related to increased choroidal thickness, overlying retinal pigment epithelial abnormalities, fundus autofluorescence changes, and an absence of subretinal fluid is described.

Is Mewds an autoimmune disease?

Autoimmune conditions include the white dot syndromes (PIC, MFC, MEWDS, BCR, APMPPE and SC)* and sarcoidosis. Infective causes include tuberculosis and syphilis and primary intraocular lymphoma can be a masquerade.

Is multifocal Choroiditis curable?

Multifocal choroiditis (MFC) is generally treated with steroid medication that can be taken orally or injected into the affected eye. These treatments may be successful in managing symptoms, though there is no permanent cure for the disease and symptoms may return.

Can Choroiditis cause blindness?

A sudden, painless decrease in vision in one or both eyes may be the first sign of Serpiginous Choroiditis. Patients may also notice blind gaps in the visual field (scotomata) or a sensation of flashes of light (photopsia).

What causes Mewds?

MEWDS results from idiopathic inflammation of the retina and choroid. It is most common in healthy, young, myopic females and typically has an acute and unilateral presentation. In one third of cases, there will be a preceding viral illness.

What is the pathophysiology of APMPPE?

APMPPE has been associated with cerebral vasculitis, acute nephritis, erythema nodosum, and neurosensory hearing loss. Laboratory testing does not appear to be helpful in making the diagnosis. Diagnostic evaluation should be directed towards excluding entities in the differential diagnosis.

What are the CNS disorders associated with APMPPE?

APMPPE-associated cerebral vasculitis can be fatal. Other associated CNS disorders that are sometimes associated with APMPPE include optic neuritis, peripheral vestibular disorders, meningoencephalitis, seizures, venous sinus thrombosis, intracerebral hemorrhage, and CVA/TIA .

What is acute posterior multifocal placoid pigment epitheliopathy (APMPPE)?

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an inflammatory chorioretinopathy which was first described by Gass in 1968 . It is classified as a White Dot Syndrome and is uncommon, with an estimated incidence of 0.15 cases per 100,000 persons .

What is the difference between placoid lesions in RPC and APMPPE?

Placoid lesions in RPC are generally more numerous and peripheral, even anterior to the equator, when compared with APMPPE . Serpiginous chorioretinitis: The clinical course of SC is generally more chronic and severe than APMPPE.

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