What are the types of haemophilia?
What are the types of haemophilia?
The three main forms of hemophilia include the following:
- Hemophilia A: Caused by a lack of the blood clotting factor VIII; approximately 85% of hemophiliacs have type A disease.
- Hemophilia B: Caused by a deficiency of factor IX.
- Hemophilia C: Some doctors use this term to refer to a lack of clotting factor XI.
How is recombinant factor VIII made?
In 1992, the U.S. Food and Drug Administration (FDA) approved recombinant factor VIII (8) concentrate, which does not come from human plasma. This concentrate is genetically engineered using DNA technology. Commercially prepared factor concentrates are treated to remove or inactivate bloodborne viruses.
How are recombinant clotting factors made?
Recombinant clotting factors are made in a lab. They don’t come from blood. They are made with recombinant DNA technology. They are concentrated into a powder form that is then mixed with sterile water and injected.
What is Ahfs in pharmacy?
AHFS DI is the most comprehensive evidence-based source of drug information complete with therapeutic guidelines and off-label uses. With expanded and revised content supported by more than 97,000 references and incorporating the advice of numerous subject matter experts, AHFS DI helps you protect your patients.
How many factors does hemophilia have?
A person with hemophilia will lack only one factor, either factor VIII or factor IX, but not both. There are two major kinds of hemophilia: hemophilia A, which is a factor VIII deficiency; and hemophilia B, which is a factor IX deficiency.
Which clotting factor deficiency causes hemophilia A?
Hemophilia A is a hereditary bleeding disorder caused by a lack of blood clotting factor VIII. Without enough factor VIII, the blood cannot clot properly to control bleeding.
Which drug has a recombinant antihemophilic factor?
SLIDESHOW. The use of RECOMBINATE (antihemophilic factor (recombinant)) rAHF is indicated in hemophilia A (classical hemophilia) for the prevention and control of hemorrhagic episodes.
What is recombinant factor IX?
Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology. It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, and has structural and functional characteristics similar to those of endogenous factor IX.
What are the therapeutic categories of the formulary?
USP Therapeutic Categories Model Guidelines
| Therapeutic Category | Pharmacologic Class | Formulary Key Drug Types |
|---|---|---|
| Analgesics | Opioid Analgesics, Short-acting | |
| Anesthetics | Local Anesthetics | |
| Antibacterials | Aminoglycosides | |
| Beta-lactam, Cephalosporins | Cephalosporin Antibacterials, 1st Generation |
What is the function of antihemophilic factor?
Antihemophilic factor is a naturally occurring protein in the blood that helps blood to clot. A lack of antihemophilic factor VIII is the cause of hemophilia A. Human antihemophilic factor works by temporarily raising levels of factor VIII in the blood to aid in clotting. Human antihemophilic factor is used…
What are the five phyla of fungi?
The five true phyla of fungi are the Chytridiomycota (Chytrids), the Zygomycota (conjugated fungi), the Ascomycota (sac fungi), the Basidiomycota (club fungi) and the recently described Phylum Glomeromycota. An older classification scheme grouped fungi that strictly use asexual reproduction into Deuteromycota, a group that is no longer in use.
What is the classification of fungi?
Classification of Fungi The kingdom Fungi contains five major phyla that were established according to their mode of sexual reproduction or using molecular data. Polyphyletic, unrelated fungi that reproduce without a sexual cycle, are placed for convenience in a sixth group called a “form phylum.” Not all mycologists agree with this scheme.
Who proposed fungal classification in 1979?
Alexopolous and Mims proposed fungal classification in 1979. They place the fungi including the slime molds in the kingdom mycetae of the super kingdom Eukaryota which, in addition, includes four other kingdoms. The division is subdivided into subdivision, classes, sub-classes, and orders. It includes phagotrophic organism devoid of cell walls.
