What does thallium 201 scan mean?
What does thallium 201 scan mean?
Thallium-201 is a radiopharmaceutical used in myocardial perfusion imaging (MPI) using either planar or single photon emission computed tomography (SPECT) techniques for the diagnosis and localization of myocardial infarction.
What happens when Thallium 201 enters the body?
The radioactive isotope thallium 201 behaves physiologically as a potassium analog, and when injected intravenously accumulates rapidly within the cells of many organs. Uptake of the isotope reflects both regional perfusion and sodium-potassium pump activity.
How does thallium chloride 201 enter the body?
Tl-201 has 73 h of physical half-life (t ½). It is produced in the cyclotron. It is administered intravenously to the patients as thallous chloride. After intravenous injection, about 88% is cleared from the blood after the first circulation.
What is the half-life of TI 201?
The radioactive half-life of Tl-201 is 73.1h, however, reported periods of extended personal radiation have been seen as far out as 61 days post-administration.
Is Thallium-201 toxic?
The radioisotope thallium-201 (as the soluble chloride TlCl) is used in small amounts as an agent in a nuclear medicine scan, during one type of nuclear cardiac stress test. Soluble thallium salts (many of which are nearly tasteless) are highly toxic, and they were historically used in rat poisons and insecticides.
What is Thallous chloride used for?
Thallous chloride Tl 201 injection is used in adults to help diagnose heart disease (eg, coronary artery disease, heart attack). It is used in certain procedures called planar scintigraphy or single-photon emission computed tomography (SPECT).
Is thallium-201 toxic?
What type of decay is Thallium-201?
Physical Characteristics. Thallium-201 is a cyclotron-produced radionuclide that decays by electron capture, with a half-life of about 73 hours. On decay, the major emissions are characteristic x-rays of the daughter product, mercury-201 (201Hg), with an energy range of 69 to 81 keV.
What is thallium used for medically?
Thallium-201 is a radiopharmaceutical agent used in the diagnosis of coronary artery disease and parathyroid hyperactivity. Other useful applications for a thallium-201 scan, like tumor diagnosis and olfacto-scintigraphy, are being explored and have shown promising results in various studies.
Is thallium 201 natural or synthetic?
Thallium is a chemical element with the symbol Tl and atomic number 81. It is a gray post-transition metal that is not found free in nature.
How is Thallium-201 made?
The herein-proposed process for producing thallium-201 resides in that a target from pure lead-206 enriched for at least 95%, is subjected to irradiation with a bunch of protons having an energy of 50 to 70 MeV, this resulting in a reaction /sup 206/Pb(p,6n)/sup 201/Bi, the irradiated target is kept for a period of …
Where is thallium-201 found?
Sources of thallium Thallium is found as a mineral in the elements crooksite, lorandite and hutchinsonite. It’s also found as a trace element in iron pyrite and obtained from this ore by roasting the mineral. Small amounts of thallium are found in manganese nodules on the ocean floor.
What is thallous chloride TL 201 injection used for?
Thallous chloride Tl 201 injection is used in adults to help diagnose heart disease (eg, coronary artery disease, heart attack). It is used in certain procedures called planar scintigraphy or single-photon emission computed tomography (SPECT).
Can thallium chloride TL 201 imaging be used for SCCA imaging?
Investigators have attempted to evaluate the role of thallium chloride Tl 201 single photon emission computed tomography (SPECT) for imaging SCCA of the extracranial head and neck.
What is the dose of Tl-201?
• Tl-201 (Thallous Chloride) is supplied in isotonic solution as a sterile, non-pyrogenic diagnostic radiopharmaceutical for intravenous administration. Thallous ions mimic potassium’s biological behavior. • Recommended radiopharmaceutical dose is approximately 1-2 millicuries.
What are the limitations of thallium chloride TL 201 in oral cancer?
The proximity of these structures to the oral cavity, oropharynx, and larynx reduces the ability of thallium chloride Tl 201 to delineate the full extent of tumor. 73
