What is the structure of picornavirus?
What is the structure of picornavirus?
Structure. The picornavirus virion is an icosahedral, nonenveloped, small (22 to 30 nm) particle. The capsid proteins encase a sense RNA strand consisting of approximately 7,500 nucleotides. The RNA carries a covalently bound noncapsid viral protein (VPg) at its 5′ end and a polyadenylated tail at its 3′ end.
What causes picornavirus?
Infection with various picornaviruses may be asymptomatic or may cause clinical syndromes such as aseptic meningitis (the most common acute viral disease of the CNS), encephalitis, the common cold, febrile rash illnesses (hand-foot-and-mouth disease), conjunctivitis, herpangina, myositis and myocarditis, and hepatitis.
How do enteroviruses work?
Enteroviruses can be spread when an infected person sneezes or coughs droplets into the air or on surfaces. A child may then breathe in droplets, or touch a contaminated surface and touch his or her eyes, mouth, or nose. The viruses are treated with supportive care such as pain medicine.
How can enteroviruses reduce the risk of infection?
Tips to reduce the risk of enterovirus infections:
- Wash hands often with soap and water for 20 seconds, especially after changing diapers.
- Avoid touching, eyes, nose, and mouth with unwashed hands.
- Avoid kissing, hugging, and sharing cups or eating utensils with people who are sick.
What does VPg stand for?
VPG
| Acronym | Definition |
|---|---|
| VPG | Virtual Picture Gallery |
| VPG | Visual Program Generator |
| VPG | Virtual Proving Ground |
| VPG | Vital Petfood Group (Denmark) |
What is the primer in picornavirus replication?
Picornaviruses have a viral protein (VPg) covalently linked to 5’ end of their genomes instead of 7-methylguanosine cap like cellular mRNAs. Virus RNA polymerases use VPg as primer. VPg as primer uses both minus and plus strand RNA synthesis. Picornavirus replication is initiated by the uridylylation of viral protein genome-linked…
What are picornaviruses and why are they important?
Picornaviruses constitute one of the most relevant viral groups according to their impact on human and animal health. Etiologic agents of a broad spectrum of illnesses with a clinical presentation that ranges from asymptomatic to fatal disease, they have been the cause of uncountable epidemics throughout history.
Is RNA synthesis possible at the 3′ end of picornavirus?
The 3′ end of picornavirus contains poly (A) tract, which be required for infectivity. RNA synthesis, though, is hypothesized to occur in this region. The 3′ end NCR of poliovirus is not necessary for negative-strand synthesis, but is important element for positive–strand synthesis.
Are There capsid antibody evasion mechanisms for picornaviruses?
Since the preservation of the capsid function is deeply rooted in the virus evolutionary dynamics, here we review the current structural evidence focused on capsid antibody evasion mechanisms from that perspective. Picornaviruses have been pivotal in the foundations of virology.
