Can balanced translocation cause Down syndrome?

Can balanced translocation cause Down syndrome?

If a parent has balanced translocation, there is an up to 15% chance of having another child with Down Syndrome.

Can you have a baby with balanced translocation?

BALANCED TRANSLOCATION AND RECURRENT MISCARRIAGE Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.

What type of translocation is Down syndrome?

Translocation Down syndrome refers to the type of Down syndrome that is caused by rearranged chromosome material. In this case, there are three # 21 chromosomes, just like there are in trisomy 21, but one of the 21 chromosomes is attached to another chromosome, instead of being separate.

Is Down syndrome An example of translocation?

Translocation Down syndrome is a type of Down syndrome that is caused when one chromosome breaks off and attaches to another chromosome. In this case, there are three 21 chromosomes, but one of the 21 chromosomes is attached to another chromosome.

What are the reproductive consequences of a balanced translocation?

Balanced chromosomal translocations may cause the loss of genetic material at breakpoints and may result in failure of spermatogenesis [3]. Individuals affected by such translocations exhibit reproductive problems such as infertility, recurrent pregnancy loss, and malformed offspring [4, 5].

What is a balanced translocation carrier?

Someone with a balanced translocation (a carrier) usually has no health or developmental problems, although they may sometimes have difficulties when they want to have children. Most balanced translocation carriers don’t know that their chromosomes are any different to anyone else’s.

What is the difference between a balanced and unbalanced translocation?

Translocations can be balanced (in an even exchange of material with no genetic information extra or missing, and ideally full functionality) or unbalanced (where the exchange of chromosome material is unequal resulting in extra or missing genes).

What causes balanced translocation?

Sometimes a section from one chromosome of a particular pair changes places with a section from a chromosome of another pair. When the two breaks do not pass through a gene and there is no gain or loss of material when the chromosomes are looked at under a microscope, it is called a balanced translocation.

What is transtranslocation Down syndrome?

Translocation Down syndrome is a type of Down syndrome that is caused when one chromosome breaks off and attaches to another chromosome. In this case, there are three 21 chromosomes but one of the 21 chromosomes is attached to another chromosome.

What chromosome is affected by Down syndrome?

The genetic material from the extra 21 chromosome is what causes the health problems that are caused by Down syndrome. In translocation Down syndrome, the extra 21 chromosome may be attached to the 14 chromosome, or to other chromosome numbers like 13, 15, or 22. In some cases, two 21 chromosomes can be attached to each other.

What are balanced translocations?

Balanced translocations are a bit different. Moms and, to a lesser extent, dads can pass Down syndrome to their kids which means a higher risk. This is even though the parents do not have Down syndrome themselves. They are silent carriers.

Can Down syndrome be passed down from one parent to another?

Yes. Translocation Down Syndrome is the only type of Down Syndrome that can be passed down from a parent who does not have features of Down Syndrome. If a parent has balanced translocation, there is an up to 15% chance of having another child with Down Syndrome.