What genes does Stat5 regulate?
What genes does Stat5 regulate?
Activation of the Immune System STAT5 regulates the transcription of the Il4 gene by binding two DNase I hypersensitivity sites, HSII and HSIII, and regulating accessibility to the gene (Zhu et al., 2003; Cote-Sierra et al., 2004).
What activates Stat5?
The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane to the nucleus. Among STAT family proteins, Stat5a and Stat5b are the two most closely related STAT proteins.
What does Stat5 do?
Stat5 proteins modulate gene transcription upon cytokine- and growth factor action. Stat5a and Stat5b proteins alone are weak activators of transcription. They can modify chromatin organization through oligomerization and they act predominantly in co-operation and interaction with other proteins.
What does STAT3 stand for?
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family.
What chromosome is STAT3 on?
| STAT3 | ||
|---|---|---|
| Location (UCSC) | Chr 17: 42.31 – 42.39 Mb | Chr 11: 100.89 – 100.94 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
What does STAT3 induce?
STAT3 signaling within the tumor microenvironment induces a procarcinogenic cytokine, IL-23, via direct transcriptional activation of the IL-23/p19 gene in tumor-associated macrophages, while inhibiting a central anticarcinogenic cytokine, IL-12, thereby shifting the balance of tumor immunity toward carcinogenesis.
What activates STAT3?
STAT3 activation within immune cells is responsible for the accumulation and the activation of immunosuppressive cells, such as Treg, Th17 and MDSCs, the differentiation of macrophages toward the M2 phenotype and the absence of functional DCs.
How do you activate STAT5 proteins?
In order to be functional, STAT5 proteins must first be activated. This activation is carried out by kinases associated with transmembrane receptors: The phosphorylated STAT5 finally goes on to form either homodimers, STAT5-STAT5, or heterodimers, STAT5-STATX, with other STAT proteins.
What ligand is involved in the activation pathway of STAT5?
In the activation pathway illustrated to the left, the ligand involved is a cytokine and the specific kinase taking part in activation is JAK. The dimerized STAT5 represents the active form of the protein, which is ready for translocation into the nucleus .
What is the difference between STAT5A and STAT5B?
High STAT5A expression is associated with imatinib resistance in chronic myeloid leukemia. STAT5 refer to STAT5A and STAT5B, however they have might have different role in hematopoietic stem cells or in Chronic myeloid leukemia cells. [review]
What is the relationship between STAT5 and cancer?
STAT5 and cancer. This constant activation is brought about either by mutations or by aberrant expressions of cell signalling, resulting in poor regulation, or complete lack of control, of the activation of transcription for genes influenced by STAT5. This leads to constant and increased expression of these genes.
