Does amikacin need monitoring?

Does amikacin need monitoring?

As with other aminoglycosides, therapeutic drug monitoring is required for amikacin due to adverse effects such as nephotoxicity and ototoxicity. The patient’s renal function should be assessed prior to and daily during therapy.

How do you dilute IV amikacin?

The solution for intravenous use is prepared by adding the contents of a 500 mg vial to 100 or 200 mL of sterile diluent such as 0.9% sodium chloride injection or 5% dextrose injection or any of the compatible solutions listed below. The solution is administered to adults over a 30 to 60 minute period.

When should amikacin trough be drawn?

The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 60 minutes after an IM injection, 30 minutes after the end of a 30-minute IV infusion, or immediately after a 60-minute IV infusion.

Can amikacin be given IV push?

Amikacin sulphate injection may be given intramuscularly or intravenously. Amikacin should not be physically premixed with other drugs, but should be administered separately according to the recommended dose and route.

Can amikacin be given IV?

Amikacin sulphate injection may be given intramuscularly or intravenously. Amikacin should not be physically premixed with other drugs, but should be administered separately according to the recommended dose and route. The patient’s pre-treatment bodyweight should be obtained for calculation of correct dosage.

How do I monitor my amikacin level?

Immunoassay techniques are the preferred methods of measurement of serum amikacin levels and produce comparable results with other testing techniques such as gas chromatography and microbiological assays. Levels may be affected by concomitant administration of other aminoglycosides.

What happens if you infuse antibiotics too fast?

Truth: Antibiotics should be given one at a time. Giving two or more at the same time can overload the kidneys and cause renal failure, especially with high doses of strong antibiotics, such as metronidazole and vancomycin.

What is the peak and trough level after amikacin infusion?

Paired levels: Check peak drug level 2 hours after and random level 6-14 hours after infusion. Consult ID pharmacy for assistance. Paired levels: Check peak drug level 30 minutes after end of infusion (goal 20-30 mg/L) and trough level immediately before next dose (goal <4 mg/L). **If amikacin 20 mg/kg is used.

What is the once daily amikacin administration and monitoring protocol?

NHS Foundation Trust Once Daily Amikacin Administration and Monitoring Protocol Amikacin is a restricted antibiotic and approval from a Consultant Microbiologist is required prior to prescribing. Review sensitivities before prescribing.

What is the highest dose of amikacin for Gram negative infection?

Dosing for Aminoglycoside High Dose Extended Interval Method For treatment of severe Gram-negative infections, dose recommended for gentamicin or tobramycin is 7 mg/kg and dose recommended for amikacin is 20mg/kg Use Total Body Weight (TBW) if Total Body Weight is less than 1.2 x Ideal Body Weight (IBW)

Does amikacin have a post-antibiotic effect?

Amikacin exhibits a concentration-dependent bactericidal activity and a post-antibiotic effect: administration of a large, once-daily dose could therefore maximize the rate of bacterial killing, with the post-antibiotic effect preventing re-growth of bacteria.