What is the difference between Micronodular and Macronodular cirrhosis?

What is the difference between Micronodular and Macronodular cirrhosis?

In the micronodular form (Laennec’s cirrhosis or portal cirrhosis), regenerating nodules are under 3 mm. In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm. Mixed cirrhosis consists of nodules of different sizes.

What does Micronodular cirrhosis mean?

Micronodular cirrhosis corresponds to liver parenchyma in which almost all nodules are smaller than 3 mm. This is the classical “Laennec cirrhosis” caused by chronic alcohol-induced liver injury (Fig. 41.1A) but which is also seen in hemochromatosis, chronic biliary disorders (Fig. 41.1B), and Wilson disease.

What causes post Hepatitic cirrhosis of the liver?

Three viruses are responsible for posthepatitic cirrhosis: hepatitis B virus, hepatitis D (also called delta) virus and hepatitis C virus formerly known as non-A, non-B virus. Delta virus is a defective organism which can replicate only when coinfection with hepatitis B virus is present.

What are the common causes of cirrhosis?

The most common causes of cirrhosis are:

• Hepatitis and other viruses.
• Alcohol abuse.
• Nonalcoholic fatty liver disease (this happens from metabolic syndrome and is caused by conditions such as obesity, high cholesterol and triglycerides, and high blood pressure)

How does HCV cause liver damage?

Hepatitis C causes damage to the liver mainly in the form of inflammation, which then leads to scarring or fibrosis. Hepatitis C results in the death of liver cells. It is uncertain whether the virus kills the cells or if it is the immune system’s response to invasion by the virus.

What is the most common cause of liver failure?

An overdose of acetaminophen is the most common cause of acute liver failure. Acute liver failure causes fatigue, nausea, loss of appetite, discomfort on your right side, just below your ribs, and diarrhea.

Is alcoholic cirrhosis Macronodular?

Cirrhosis is classified based on morphology or etiology. Morphologically, cirrhosis is (1) micronodular, (2) macronodular, or (3) mixed. This classification is not as clinically useful as etiologic classification.

Does HCV affect the liver?

Chronic hepatitis C can be a lifelong infection if left untreated. Chronic hepatitis C can cause serious health problems, including liver damage, cirrhosis (scarring of the liver), liver cancer, and even death.

What is macronodular cirrhosis of the liver?

What Is Macronodular Cirrhosis? These are larger nodules divided by wider scars and distributed irregularly throughout the liver, normally caused by chronic hepatitis. It involves nodules that are 3+ millimeters large. What About Liver Lesion?

What is the most common cause of micronodular cirrhosis?

Remember that the most prevalent cause of micronodular cirrhosis is an alcoholic liver disease (ALD). This often occurs progressively after many years of alcohol overuse (heavy drinking).

What is a macro node in the liver?

That is a specific type of liver cirrhosis or liver scarring. As the name suggests, this involves large nodules that are 3+ millimeters. There are three types of cirrhosis related to the node sizes: macro, micro, and mixed.

What is the gross morphologic appearance of cirrhotic liver?

The gross morphologic appearance of a cirrhotic liver is categorized by the size of the parenchymal nodules: micronodular, macronodular, or mixed. Micronodular cirrhosis is characterized by regenerative nodules of relatively uniform and small size.