What is coagulation factor VIII (F8)?
What is coagulation factor VIII (F8)?
F8 (Coagulation Factor VIII) is a Protein Coding gene. Diseases associated with F8 include Hemophilia A and Hemophilia. Among its related pathways are Metabolism of proteins and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and copper ion binding.
Can human FVIII gene transfer without in vivo selection introduce immune tolerance?
Human FVIII gene transfer without in vivo selection of manipulated cells can introduce immune tolerance in hemophilia A mice and this immune tolerance is CD4 (+) T cell mediated.
Does factor VIII interact with protein C to increase heart disease risk?
The combination of a high factor VIII and a low protein C increased coronary heart disease risk synergistically. The K408 in the A2 domain of factor VIII provides an interactive-site for FX in the factor Xase complex.
Does galgal-1 binding influence the procoagulant activity of FVIII?
Gal-1 binding can influence the procoagulant activity of FVIII. Our results confirm the rare event of Haemophilia A and haemophilia B in the same patient originating from two distinct genetic defects in F8 and F9 genes. In general, NGS provides an effective approach to screen for different HA causing mutation types in the F8 gene.
What is the role of kynureninase in NAD cofactors?
Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.
Is the FXIII-A val34leu polymorphism associated with Ich risk in Caucasian populations?
The results of a combined analysis showed no significant association between the FXIII-A Val34Leu polymorphism and ICH risk in the overall population. The results of this meta-analysis suggest that the FXIII-A Val34Leu polymorphism is not associated with ICH risk in a Caucasian population.
