What is bovine thrombin?
What is bovine thrombin?
Product Description. Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
How do you administer thrombin?
For routine use, reconstitute THROMBIN-JMI with sterile isotonic saline at a recommended concentration of 1,000 to 2,000 International Units per mL. Where bleeding is profuse, as from abraded surfaces of liver or spleen, concentrations of 1,000 International Units per mL may be required.
How do you make a thrombin solution?
Stock solutions can be prepared at a concentration of 100 units/mL in a 0.1% (w/v) BSA solution. Stock solutions remain active for one week at 0–5 °C. Solutions are most stable at pH 6.5, as a pH >7 will greatly reduce thrombin activity.
What is the generic name for thrombin?
Recothrom, Thrombogen (thrombin) dosing, indications, interactions, adverse effects, and more.
How do you take thrombin topical?
Use In Conjunction With Absorbable Gelatin Sponge Immerse sponge strips of the desired size in THROMBIN-JMI solution. Knead the sponge strips vigorously with moistened, gloved fingers to remove trapped air, thereby facilitating saturation of the sponge. Apply saturated sponge to bleeding area.
Can topical thrombin cause intravascular thrombosis?
Disadvantages. Thrombin is ineffective in patients who suffer from afibrinogenemia because fibrinogen will not be present in the patient’s blood. Care should be exercised to not use thrombin directly on larger vessels because systemic absorption may lead to intravascular thrombosis.
What is thrombin solution?
RECOTHROM, Thrombin topical (Recombinant), is a topical thrombin. indicated to aid hemostasis whenever oozing blood and minor bleeding from. capillaries and small venules is accessible and control of bleeding by standard. surgical techniques (such as suture, ligature, or cautery) is ineffective or.
What is thrombin topical used for?
Thrombin topical is used to help control minor bleeding and oozing during surgery. Thrombin is a protein that is produced naturally in the body. Recothrom® is a man-made protein produced to replicate the naturally occurring thrombin in the body. It is used to stop bleeding by helping the blood to clot.
How do you mix topical thrombin?
Do not inject.
- Reconstitution. For routine use, reconstitute THROMBIN-JMI with sterile isotonic saline at a recommended concentration of 1,000 to 2,000 International Units per mL.
- Administration. Topical Application Of THROMBIN-JMI.
- Dosage Forms And Strengths.
- Storage And Handling.
What is another name for thrombin?
Thrombin is available under the following different brand names: Recothrom, Thrombogen, and Thrombin JMI.
What are the available Thrombin-JMI products?
THROMBIN-JMI is available in the Gelfoam-JMI™ Sponge Kit (Gelfoam ® Absorbable Gelatin Sponge, USP and Thrombin, Topical (Bovine) U.S.P., Thrombin-JMI ®, 5,000 IU vial with 5 mL diluent. ( 3)
How do you use a thrombin syringe?
Insert the nasal drug delivery device into the naris and spray the THROMBIN-JMI thrombin solution onto the nasal mucosa through the nasal drug delivery device by depressing the syringe plunger using mild or moderate pressure on the syringe plunger.
How do you use affaffix thrombin spray?
Affix spray tip by pushing down and turning clockwise until the spray tip locks in place. To spray, depress the syringe plunger in a normal fashion to dispense the THROMBIN-JMI Thrombin solution through the tip in a fine spray.
What are the indications of thrombin?
INDICATIONS. THROMBIN -JMI is topical bovine thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical. In various types of surgeries,…
