What is a high UIBC level?

What is a high UIBC level?

Optimal Result: 111 – 343 µg/dL, 19.87 – 61.40 µmol/L, or 111.00 – 343.00 umol/L. Unsaturated iron-binding capacity (UIBC) is a blood test most frequently used along with a serum iron test and a total iron-binding capacity test (TIBC) to evaluate people suspected of having either iron deficiency or iron overload.

What does low UIBC mean in a blood test?

UIBC represents the portion of iron binding sites on transferrin that are not occupied by iron. Therefore, a low UIBC indicates that transferrin is highly saturated with iron, a finding consistent with hereditary hemochromatosis (HH).

What is normal unsaturated iron binding capacity?

The unsaturated iron-binding capacity (UIBC) is measured using radioactive iron or spectrophotometric approaches. The sum of the UIBC and the plasma iron is the total iron-binding capacity (TIBC). Direct measurement of the TIBC may also be performed. The iron-binding capacity reference range is 255-450 μg/dL.

What is normal iron binding range?

Normal Results Normal value range is: Iron: 60 to 170 micrograms per deciliter (mcg/dL) or 10.74 to 30.43 micromoles per liter (micromol/L) TIBC: 240 to 450 mcg/dL or 42.96 to 80.55 micromol/L. Transferrin saturation: 20% to 50%

Is haemochromatosis a disease?

Haemochromatosis (iron overload disorder) is one of the most common hereditary diseases. Around one in 200 Caucasian Australian people have a genetic predisposition to this disease – meaning that they may get it.

Is UIBC the same as transferrin?

Some laboratories measure UIBC, some measure TIBC, and some measure transferrin. UIBC measures the unsaturated binding capacity of transferrin. A complete blood count (CBC) is highly recommended for anyone at risk for an iron disorder.

What does it mean if your iron binding capacity is high?

High levels of iron may indicate: hemolytic anemia or hemolysis: your body doesn’t have enough healthy red blood cells. liver conditions: such as hepatic necrosis (liver failure) and hepatitis.

What if iron binding capacity is high?

High levels of iron may indicate: hemolytic anemia or hemolysis: your body doesn’t have enough healthy red blood cells. liver conditions: such as hepatic necrosis (liver failure) and hepatitis. iron poisoning: you’ve taken more than the recommended dose of iron supplements.

What causes low UIBC levels?

A high UIBC, TIBC, or transferrin normally indicates iron deficiency (pregnancy and oral contraceptives can also cause increased levels). A low UIBC, TIBC, or transferrin usually occurs in people with iron overload.

What does UIBC in blood work mean?

Unsaturated iron-binding capacity (UIBC) is a blood test most frequently used along with a serum iron test and a total iron-binding capacity test (TIBC) to evaluate people suspected of having either iron deficiency or iron overload.

What does high TIBC and UIBC mean?

A high TIBC test result may indicate that the patient has iron deficiency. A low TIBC results may indicate that the patient has haemochromotosis, certain forms of anaemia, malnutrition or cirrhosis.