What is humanized mouse model?
What is humanized mouse model?
A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context for understanding of human-specific physiology and pathologies.
What is SLE model?
Mouse models have contributed to significant progress in uncovering mechanisms by which lupus develops and sustains disease conditions and in evaluations of therapeutic efficacy. Pristane-induced lupus is a well-established model of murine lupus.
What are VelocImmune mice?
VelocImmune is a novel platform for the production of fully-human therapeutic antibodies in vivo. Unlike other technological platforms, VelocImmune mice take advantage of the normal murine humoral response to create high affinity therapeutic antibodies that do not require additional engineering to drug characteristics.
What is an orthotopic mouse model?
Orthotopic models involve implantation of tumor cell lines or patient-derived cell xenografts into animal tumor models into the organ or tissue which matches the tumor histotype. This creates a more disease-relevant environment for the assessment of tumor growth, which can be analyzed by optical imaging.
What’s the difference between Yukon SLE and SLT?
The standard base SLE offers a good number of high-class features while enjoying the comfort and style of the Yukon XL. The SLT Standard Edition and SLT offer just a little bit more as far as features, but still provides the same power and performance.
What are immuneimmunodeficient mice?
Immunodeficient mouse models, particularly severe combined immunodeficient (Prkdc scid and Rag1 null) mice, are very useful models for immunology, infectious disease, cancer, stem cell biology and other research.
What do mouse models tell us about systemic lupus erythematosus?
Mouse models have contributed to the bulk of knowledge on Systemic Lupus Erythematosus (SLE). Nevertheless, substantial differences exist between human and mouse immune system.
Are there any murine models of lupus?
There are perhaps more applicable murine models of lupus than any other human disease. There are spontaneous models of lupus, inducible models of lupus, transgenic-induced lupus, gene knockout induced lupus and humanised mouse models of lupus.
What is the prognosis of Lupus in mice?
They do develop splenomegaly and hypergammaglobulinemia. 3 They do not manifest other clinical manifestations of lupus such as rash or arthritis. Disease develops slowly, primarily after 6 months of age, with 50% mortality in female mice at 9 months of age and in male mice at 15 months of age.
