What side effect can be a long term effect of bisphosphonates?

What side effect can be a long term effect of bisphosphonates?

Long-term bisphosphonate therapy has been linked to a rare type of thigh fracture. This injury, known as atypical femoral fracture, is similar to a stress fracture, causing pain that begins subtly and can gradually worsen. If not identified early on, a complete fracture of the thighbone can occur.

Which of the following is a rare adverse effect associated with long term use of bisphosphonate therapy?

Uncommon side effects of bisphosphonate therapy include fractures of the femur (such as a hip fracture) and inflammatory eye disease.

Should bisphosphonates be continued indefinitely?

In those patients who remain at high risk of fracture in spite of five years’ treatment with bisphosphonates, for example patients with multiple vertebral fractures or very low BMD, it is recommended that treatment continues indefinitely on the basis that any risks are outweighed by the benefits.

Is Forteo a bisphosphonate?

Fosamax and Forteo belong to different drug classes. Fosamax is a bisphosphonate and Forteo is a synthetic parathyroid hormone.

Why do bisphosphonates cause osteonecrosis of the jaw?

The mechanism by which BPs cause osteonecrosis is not proven but is probably due to a combination of decreased bone remodelling, poor wound healing, and an antiangiogenic effect leading to ischaemic changes and subsequent necrosis in response to a local traumatic insult.

What are adjuvant bisphosphonates?

Adjuvant bisphosphonates were found to reduce bone recurrence and improve survival in postmenopausal patients with nonmetastatic breast cancer. In this guideline, postmenopausal includes patients with natural menopause or that induced by ovarian suppression or ablation.

Can Prolia cause numbness?

Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. If you have low calcium levels, you should not take Prolia. (To learn more, see the “Precautions for Prolia” section below.)

Which osteoporosis medication has the least side effects?

Raloxifene. Another medication commonly used to treat osteoporosis is the Raloxifene drug Evista. Evista minimizes bone loss by producing an estrogen-like effect in the body. One positive side effect associated with Evista is that it has been shown to lower the risk of developing breast cancer.

Is it safe to take Fosamax to treat osteoporosis?

Fosamax helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a full glass of water, must be strictly followed. The optimal length of therapy remains unknown.

How do bisphosphonates treat osteoporosis?

Bisphosphonates, like alendronate ( Binosto, Fosamax ), ibandronate acid ( Boniva ), and risedronic acid ( Actonel, Atelva ) treat osteoporosis by keeping the body from breaking down bone. You take Boniva once a month, while the others can be taken weekly.

Is Prolia bisphosphonates medication?

Prolia, the New Darling in the Treatment of Osteoporosis. Differently from the bisphosphonates. Prolia is what is called a monoclonal antibody (hint, a medication whose generic name ends in – mab is a monoclonal antibody). Prolia inhibits the activation of osteoclasts which break down bone.