What are the side effects of maraviroc?
What are the side effects of maraviroc?
Maraviroc may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- cough, runny nose, or other cold symptoms.
- muscle or joint pain.
- pain, burning, numbness, or tingling in the hands or feet.
- dizziness.
- diarrhea.
- constipation.
- painful or difficult urination.
Where is CCR4?
Among the various T-cell subsets, CCR4 is predominantly expressed by Th2 cells, cutaneous lymphocyte antigen-positive skin-homing T cells and Treg cells. Thus, CCR4 attracts much attention for its possible clinical applications in diseases involving these T-cell subsets.
What does the CCR3 gene stand for?
GeneCards Summary for CCR3 Gene. CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Folliculotropic Mycosis Fungoides and Orofacial Granulomatosis. Among its related pathways are Lung fibrosis and Peptide ligand-binding receptors.
What is monomeric CCR3 receptor?
The monomeric CCR3 receptor is the minimal functional unit in cellular signal transduction. Agonists increase dimers and oligomers at high concentrations. Antagonists do not affect oligomeric status. Monomeric CCR3 exhibits a stronger chemotactic response in the migration assay of stably transfected CCR3 cells.
What is the role of CCR3 in ASM cells?
CCR3 is strongly expressed by ASM cells in vitro and in vivo. Protection against cell death by CCR3 activation is dependent on p42/44 MAPK but does not affect caspase 3 mediated apoptosis. Methylation of CpG sites at the GATA elements in the regulatory regions fine-tunes CCR3 transcription.
Where are CCR5 and CCR3 receptors expressed in spermatozoa?
CCR5 and CCR3 receptors are expressed on the head region of human spermatozoon Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression. This protein mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13.
