What is anti CD2?

What is anti CD2?

Anti-CD2 treatment provides targeted immunomodulatory properties that have demonstrated clinical usefulness to condition the immune system and to treat transplant rejection. The treatment is species-specific due to structural CD2 antigen differences between nonhuman primates and humans.

Which structure will express CD8 surface antigen by immunohistochemistry?

cytotoxic T cells
The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population.

What is CD16 in immunology?

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, and macrophages. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction.

What are CD4 markers?

Also known as T4, and Leu-3, CD4 is a 55 kDa type I transmembrane glycoprotein and member of the immunoglobulin superfamily. Primarily described as a marker for T cell subsets it can also be found on NKT cells, innate lymphoid cells and macrophages.

Do NK cells need costimulation?

We have hypothesized that, similar to the proliferation of T and B lymphocytes, optimal proliferation of NK cells requires costimulatory signals as well as a primary mitogenic stimulus. Evidence for costimulation by both soluble cytokines and cell contact-dependent factors is presented.

Where does CD8 bind to MHC?

For both CD8αα and CD8αβ, the main binding interaction is with a protruding loop in the α3 domain of the MHC class I molecule (CD loop), corresponding to residues 220–228 (Figures 1B,D). This loop is flexible in the absence of CD8, but is stabilized by CD8 binding.

What is the function of CD11c?

CD11c has been proposed to function in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T cell proliferation by Langerhans cells. Using assays to quantify CD11c-mediated cell adhesion, we demonstrate that CD11c recognizes ICAM-2 and VCAM-1.

Do B cells express CD16?

Early in development, murine B-lineage progenitor cells express two classes of IgG Fc receptors (FcgammaR) designated as FcgammaRII (CD32) and FcgammaRIII (CD16), but mature B lymphocytes only express FcgammaRII (CD32), which functions as an inhibitor of B-cell activation when it is induced to associate with mIgM.

What is cdcd2 antibody?

CD2 Antibodies. CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells.

What does CD2 bind to on T cells?

The CD2 receptor on T cells binds to LFA-3 (CD58) or CD48 expressed on a wide variety of cells. Antibodies to CD2 have been shown to induce T cell proliferation, but their function is dependent on TCR expression.

What is CD2 used for in immunohistochemistry?

In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.

Is CD2 an immunoglobulin?

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion. CD2 has been shown to interact with CD2BP2, Lck and PSTPIP1.