What does AUC mean in pharmacology?

What does AUC mean in pharmacology?

area under the curve
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

What does AUC definition?

AUC stands for “Area under the ROC Curve.” That is, AUC measures the entire two-dimensional area underneath the entire ROC curve (think integral calculus) from (0,0) to (1,1).

What is AUC and Cmax?

Abstract. In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.

What are the units for AUC pharmacokinetics?

The unit of AUC is the unit of time multiplied by the unit of radioactivity concentration, usually min*kBq/mL. The AUC from 0 to infinite time, AUC0-∞, can be used to estimate the total clearance of radiopharmaceuticals, CLT.

What does high AUC mean?

The Area Under the Curve (AUC) is the measure of the ability of a classifier to distinguish between classes and is used as a summary of the ROC curve. The higher the AUC, the better the performance of the model at distinguishing between the positive and negative classes.

Why is AUC important pharmacology?

The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure.

What does increased AUC mean?

The AUC and Css indicate the total exposure to a drug and are usually related to the drug’s response. An increase in Cl will decrease AUC and a decrease in Cl increases AUC.

What is a good AUC?

AUC can be computed using the trapezoidal rule. In general, an AUC of 0.5 suggests no discrimination (i.e., ability to diagnose patients with and without the disease or condition based on the test), 0.7 to 0.8 is considered acceptable, 0.8 to 0.9 is considered excellent, and more than 0.9 is considered outstanding.

What are PK parameters?

PK parameters are used to translate and understand how a drug interacts with the body. PK parameters tell drug developers: how the drug is absorbed after administration. how the body distributes the drug into different bodily compartments or tissues. how the body metabolizes or degrades the drug.

What factors affect AUC?

The AUC is influenced by external factors such as drug dose and schedule, as well as patient-specific factors such as age, gender, height, weight, concomitant medications and habits, genetics (inherited variations in drug metabolizing enzymes, drug transporters, and/or drug targets), and clearance (which depends on …

What does the AUC tell you pharmacokinetics?

In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry).

What does AUC stand for and what is it?

Area Under the Curve (AUC) is a mathematical method of measuring drug concentrations. Area Under the Curve The “curve” referred to in AUC is the curve on a concentration-versus-time graph. The concentration of a drug in the patient’s blood is plotted against the time when the sample was taken.

What does “AUC” mean in chemotherapy?

The calvert formula is used to determine the dose of chemotherapy drugs such as 5-fluorouracil and carboplatin. AUC is a quick measure of how much of the drug an individual has been exposed to in a given amount of time. Keeping the AUC within a defined range helps limit the dangerous side effects of chemotherapy.

What is AUC dosing?

Description. The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the drug from the body and the dose administered.

What is pharmacology all about?

Pharmacology. Pharmacology, branch of medicine that deals with the interaction of drugs with the systems and processes of living animals, in particular, the mechanisms of drug action as well as the therapeutic and other uses of the drug.