How do you give voriconazole injection?

How do you give voriconazole injection?

VFEND I.V. for Injection requires reconstitution to 10 mg/mL and subsequent dilution to 5 mg/mL or less prior to administration as an infusion, at a maximum rate of 3 mg/kg per hour over 1 to 3 hours. Administer diluted VFEND I.V. by intravenous infusion over 1 to 3 hours only.

What is voriconazole dosing?

When voriconazole is coadministered with efavirenz the dose of voriconazole should be increased to 400 mg every 12 hours and the dose of efavirenz should be decreased to 300 mg every 24 hours (see sections 4.2, 4.3 and 4.5).

How strong is voriconazole?

Oral voriconazole is supplied as film-coated tablets containing 50 mg or 200 mg of active drug. For the treatment of fungal infections in adults, the dose of voriconazole is 400 mg orally every 12 hours for 2 doses, followed by a maintenance dose of 200 mg orally every 12 hours.

How fast does voriconazole work?

Voriconazole, unlike other broad-spectrum triazoles, is available in both oral and intravenous dosage forms. The intravenous formulation is solubilized in sulfobutyl ether β-cyclodextrin (SBECD). Steady-state levels are attained after 5–6 days when 3–6 mg/kg/day of voriconazole is administered.

Does voriconazole affect kidney?

Renal damage during voriconazole therapy occurred in 13 (30.2%) patients with initial normal renal function and in 4 (15.4%) in patients with impaired renal function (P = 0.257).

Is voriconazole a steroid?

Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium.

How do you treat lung fungus?

Fungus balls in the lungs (aspergillomas) usually do not require treatment with drugs and do not usually respond to drugs. If these balls cause bleeding (causing people to cough up blood) or other symptoms, they may need to be removed surgically.

Can voriconazole cause Aki?

Acute kidney injury (AKI), assessed by RIFLE criteria, was more frequent in the fluconazole vs. the caspofungin group (p < 0.01); incidence of AKI in the voriconazole group was not significantly different than found in the other two groups.

What is Sbecd?

Since voriconazole has limited water solubility, the intravenous (IV) voriconazole formulation includes the vehicle sulfobutylether-beta-cyclodextrin sodium (SBECD). SBECD is comprised of a multitude of polymeric structures with varying degrees of substitution.

What happens with 200 mg Viagra?

In fact, above 100 mg, pretty much all you get out of more Viagra is more side effects. Abnormal vision is a problem only 11% of the time with 100 mg, but jumps to between 40% and 50% with 200 mg, for instance. One-quarter of men who use 200 mg experience facial flushing, while 15% report stomach problems.

What is voriconazole 200mg?

Voriconazole drug substance is a white to light-colored powder. VFEND I.V. is a white lyophilized powder containing nominally 200 mg voriconazole and 3200 mg sulfobutyl ether beta-cyclodextrin sodium in a 30 mL Type I clear glass vial. VFEND I.V. is intended for administration by intravenous infusion.

Is there a 200 mg Viagra?

Viagra 200 mg cannot be used as a “safety net” if you are unsure of yourself. This is a very powerful drug that contains too much sildenafil to be used in such way. In some cases, it is better to choose the dose of 50 mg or try a “milder” drug (e.g. Cialis 5 mg ).