What is the function of GLUT2?
What is the function of GLUT2?
GLUT2 is the major glucose transporter inβ -cells of pancreatic islets and hepatocytes. In both cell types, GLUT2 mediates the facilitated diffusion of glucose across the cell membranes, and then intracellular glucose metabolism is initiated by the glucose-phosphorylating enzyme, hexokinase IV or glucokinase.
What is the difference between GLUT1 and GLUT2?
GLUT1 (SLC2A1) was the first to be cloned, and this gene is highly expressed in red blood cells and the blood–brain barrier. GLUT2 (SLC2A2) is expressed in the intestine and kidney where it plays an important role in facilitated glucose transport across the basolateral membrane.
What does GLUT2 stand for?
Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes.
What is the difference between glut and Sglt?
GLUTs are expressed in a wide variety of cells, from red blood cells to liver to the brain….GLUT vs SGLT: Differences between GLUT and SGLT.
| GLUT Glucose Transporter | SGLT Sodium-Glucose Cotransporter |
|---|---|
| Transports glucose | Co-Transports both glucose and sodium |
| Uniport | Symport |
| Can also transport galactose and fructose | n/a |
Is GLUT2 bidirectional?
The hepatic glucose transporter, GLUT2, facilitates bidirectional glucose transport across the hepatocyte plasma membrane under insulin regulation.
How many gluts are there?
14 GLUTS
The GLUT or SLC2A family are a protein family that is found in most mammalian cells. 14 GLUTS are encoded by human genome. GLUT is a type of uniporter transporter protein.
Is GLUT 2 bidirectional?
Where is glut 7 found?
GLUT7 has a high affinity for both glucose and fructose and is located in cells of the small intestine, colon, testis and prostate (Li et al. 2004).
Is GLUT a Uniport?
The GLUT or SLC2A family are a protein family that is found in most mammalian cells. GLUT is a type of uniporter transporter protein.
Where is GLUT4 found?
GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in intracellular vesicles referred to as GLUT4 storage vesicles (GSVs).
Where is glut 5 found?
intestinal epithelial cells
GLUT5 (SLC2A5) is a high-affinity fructose transporter primarily expressed at the apical surface of intestinal epithelial cells but also at lower levels in testis, kidney, brain, skeletal muscle and white adipose tissue (WAT)15.
What is the use of glut in OpenGL?
GLUT makes it considerably easier to learn about and explore OpenGL programming. GLUT provides a portable API so you can write a single OpenGL program that works on both Win32 PCs and X11 workstations. GLUT is designed for constructing small to medium sized OpenGL programs.
What is the difference between GLUT5 and GLUT7?
GLUT5 is primarily a fructose transporter located on cells of the small intestine, testes and kidney where it plays important physiological and pathological roles. GLUT7 has a high affinity for both glucose and fructose and is located in cells of the small intestine, colon, testis and prostate (Li et al. 2004).
What is the difference between SGLT and Glut?
All members of the SGLT family are 60- to 80-kDa proteins containing 580–718 amino acids. GLUTs are proteins comprising 12 membrane-spanning regions with intracellularly located amino and carboxyl terminals. The amino acid sequence of GLUT proteins has been found to show 28–65 % identity against GLUT 1.
What is the current version of glut?
Because GLUT is window system independent (as much as possible), GLUT can be implemented for window systems other than X. Implementations of GLUT for OS/2, NT & Windows 95, and the Mac have ben implemented, but only the Win32 and X11 versions are part of the official GLUT source code distrbution. The current version of the GLUT API is 3.
