Does indole-3-carbinol lower estrogen?
Does indole-3-carbinol lower estrogen?
Epidemiological, laboratory, animal and translational studies support the efficacy of I3C. Whereas estrogen increases the growth and survival of tumors, I3C causes growth arrest and increased apoptosis and ameliorates the effects of estrogen.
What foods contain indole-3-carbinol?
Indole-3-carbinol is formed from a substance called glucobrassicin found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked. It can also be produced in the laboratory.
Does indole-3-carbinol lower testosterone?
The decrease of testosterone levels in I3C-treated group could be due to the inhibitory effect of I3C on the androgen receptors transcription [66].
Does I3C increase estrogen?
Indole-3-Carbinol/Diindolylmethane Studies have shown that increasing the intake of vegetables of the cabbage family or taking I3C or DIM as a dietary supplement significantly increases the conversion of estrogen from cancer-producing forms to nontoxic breakdown products.
What foods are high in indoles?
Indole-3-carbinol is a substance found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. It can also be produced in the laboratory. Indole-3-carbinol is used for prevention of breast cancer, colon cancer, and other types of cancer.
Does cooking destroy indole-3-carbinol?
Cooking brassicas will destroy some of the I3C content, but eating them raw has a major down-side – these raw veggies contain high levels of acids that prevent nutrients from being absorbed, compounds that interfere with thyroid hormone production and may contribute to kidney stones [14].
Can you eat too much cruciferous vegetables?
Bottom Line: Cruciferous vegetables are healthy and nutritious. However, they contain thiocyanates, which can block iodine absorption. People with thyroid problems should not eat very large amounts of these veggies.
Does cooking destroy indole 3 carbinol?
Does indole-3-carbinol help with weight loss?
Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice. J Nutr Biochem.
What is the difference between dim and indole-3-carbinol?
DIM is formed naturally when I3C is broken down in the gut. Unlike I3C, there are no published human studies on DIM. In fact, there are few published studies at all….ANTI-CANCER EFFECTS OF I3C.
| I3C | DIM | |
|---|---|---|
| Inhibits Growth of Estrogen Receptor Positive Breast Cancer Cells | • | • |
What does indole Forte do?
Indole Forté™ provides a spectrum of indole compounds to support estrogen balance, detoxification enzymes of the liver, and exert other cell-protective benefits in both men and women.
What is indindole-3-carbinol (IC3)?
Indole-3-carbinol (IC3) is a substance that the body produces when it breaks down glucobrassicin. Where do you find glucobrassicin? It’s a compound found naturally in cruciferous vegetables like cauliflower and broccoli. You can also find IC3 sold in supplement form.
Can indole-3-carbinol be used to treat cancer?
The central claim about indole-3-carbinol is that it may help prevent certain cancers. However, that doesn’t mean you should use it to treat cancer after you have been diagnosed.
How much indindole-3-carbinol can you take without a prescription?
Indole-3-Carbinol (I3C) I3C is available without a prescription as a dietary supplement, alone or in combination products. Dosage ranges between 200 mg/day and 800 mg/day (95). I3C supplementation increased urinary 2HE1 concentrations in adults at doses of 300 to 400 mg/day (39).
How much indindole-3-carbinol should I take for neoplasia?
Indole-3-Carbinol (I3C) I3C doses of 200 mg/day or 400 mg/day improved the regression of cervical intraepithelial neoplasia (CIN) in a preliminary clinical trial (75). I3C in doses up to 400 mg/day has been used to treat recurrent respiratory papillomatosis (see Disease Treatment) (85, 86).
