What is drug DNA interaction?
What is drug DNA interaction?
The interaction of drugs with DNA is a significant feature in pharmacology and plays a vital role in the determination of the mechanisms of drug action and designing of more efficient and specifically targeted drugs with lesser side effects. Several instrumental techniques are used to study such interactions.
How can we monitor drug DNA interaction?
The study of drug–DNA interactions could be carried out by UV–Visible absorption spectroscopy by monitoring the changes in the absorption properties of the drug or the DNA molecules. Usually, molecules used as ligands show an absorption band that can be clearly distinguished in the visible region.
What drugs use DNA?
Drug DNA Interaction
- Liposomal Daunorubicin.
- Proflavine.
- DNA Damage.
- DNA.
- Doxorubicin.
- Mitomycin.
- Ethidium.
- Intercalating Agent.
Why do anticancer agents target DNA?
DNA as carrier of genetic information is a major target for anticancer drug interaction because of the ability to interfere with transcription and DNA replication, a major step in cell growth and division.
How did DNA improve medicine?
By modifying DNA it is possible that genetic diseases can be eliminated. DNA can be used to screen people for genetic diseases, eg breast cancer. It has also been used to reverse mutations that cause blindness, to stop cancer cells from multiplying and make some cells resistant to AIDS .
How can DNA change?
DNA is a dynamic and adaptable molecule. As such, the nucleotide sequences found within it are subject to change as the result of a phenomenon called mutation. Depending on how a particular mutation modifies an organism’s genetic makeup, it can prove harmless, helpful, or even hurtful.
Why do anticancer drugs target topoisomerase?
DNA topoisomerases, especially type IIA topoisomerases, are proved therapeutic targets of anticancer and antibacterial drugs. Clinically successful topoisomerase-targeting anticancer drugs act through topoisomerase poisoning, which leads to replication fork arrest and double-strand break formation.
Which is an anticancer drug?
anticancer drug, also called antineoplastic drug, any drug that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include alkylating agents, antimetabolites, natural products, and hormones.
What is DNA-drug interaction?
DNA-Drug Interaction Transcription and replication are vital to cell survival and proliferation as well as for smooth functioning of all body processes. DNA starts transcribing or replicating only when it receives a signal, which is often in the form of a regulatory protein binding to a particular region of the DNA.
What is the role of DNA in pharmacology?
The interaction of drugs with DNA is a significant feature in pharmacology and plays a vital role in the determination of the mechanisms of drug action and designing of more efficient and specifically targeted drugs with lesser side effects. Several instrumental techniques are used to study such interactions.
Why DNA as a target for cytotoxic anticancer drugs?
DNA has been known to be the cellular target for many cytotoxic anticancer agents for several decades. Understanding how drug molecules interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.
Do non-covalent compound–DNA interactions affect molecular and biochemical pathways?
Although the impact of non-covalent compound–DNA interactions on convoluted molecular and biochemical pathways is not well characterized, the most important effects include DNA conformational and related structural perturbations, interference with normal DNA protein interactions]
