What drug is ototoxic and nephrotoxic?
What drug is ototoxic and nephrotoxic?
It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity.
What drugs cause ototoxicity?
List of Ototoxic Medications
- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including aspirin, ibuprofen, and naproxen.
- Certain antibiotics, including aminoglycosides.
- Certain cancer medications.
- Water pills and diuretics.
- Quinine-based medications.
Which drug has least nephrotoxic and ototoxic?
Streptomycin is the least nephrotoxic aminoglycoside; however, it is highly ototoxic. Cross-resistance between streptomycin and other aminoglycosides and polypeptides is not common, and, therefore, kanamycin, amikicin, capreomycin, and viomycin can be used as second-line agents to treat MDR-TB.
Which of the following drugs most commonly causes hearing impairment?
The following are commonly used OTC and prescription drugs that could damage patients’ hearing:
- Aspirin. Aspirin-induced temporary hearing loss is normally associated with large doses, or 8 to 12 pills per day.
- Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
- Antibiotics.
- Chemotherapy Drugs.
- Loop Diuretics.
Which medication is most likely to cause nephrotoxicity?
The most common drugs that cause DIKD include antibiotics, anti-rejection medications, antiviral agents, non-steroidal anti-inflammatory agents, anti-ulcer agents and chemotherapy. Most studies have defined nephrotoxicity as 0.5 mg/dL or 50% rise in Scr over 24–72 h time frame and a minimum 24–48 h of drug exposure.
Can ceftriaxone cause hearing loss?
The most striking observation in the patients who received ceftriaxone was the substantially reduced frequency of moderate-to-profound sensorineural hearing loss; other neurologic abnormalities were rare and occurred at similar rates in both treatment groups.
Does amoxicillin cause ototoxicity?
Conclusion. There appears a causal association between amoxicillin and hearing loss that requires further substantiation with better epidemiologic studies.
Can cipro cause hearing loss?
Topical ciprofloxacin is a safe and uncomplicated ototoxic drug that is an effective antibiotic used in the treatment of refractory chronic otitis those dregs such as pseudomonas aerogenusa and staphylococci resistant to methicillin are responsible for it, which in the usual doses has not harmful effects on hearing …
Is Lasix ototoxic?
Some classes of diuretics, commonly called water pills, have ototoxic properties. These drugs include Lasix (furosemide) and Demadex (torsemide), and can cause ringing in the ears or hearing loss that usually goes away when the medication is discontinued.
Which antibiotics cause nephrotoxicity and ototoxicity?
It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity.
What are the drugs that cause nephrotoxicity?
Medications causing nephrotoxicity: Adefovir. Kanamycin. Cyclophosphamide. Cisplatin: Cisplatin is one of the most widely used and most potent chemotherapy drugs. Cisplatin, while highly toxic, is one of the most heavily Vancomycin: Vancomycin is a tricyclic glycopeptide antibiotic originally
What are the different types of ototoxic medications?
The list includes aminoglycosides and other antibiotics, platinum-based chemotherapy medications, salicylates, quinine and loop diuretics. The method of action of ototoxic medications differs somewhat among the various drugs.
What are the drug-induced ototoxicity effects of neomycin?
Drug-Induced Ototoxicity. Kanamycin and amikacin are close to neomycin in cochleotoxic potential and are both capable of causing profound, permanent hearing loss while sparing balance. Gentamicin and tobramycin have vestibular and cochlear toxicity, causing impairment in balance and hearing. Vancomycin can cause hearing loss,…
