Does artemisinin treat malaria?
Does artemisinin treat malaria?
Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission.
Is malaria resistant to artemisinin?
Because 90% of malaria cases and deaths are currently reported in Africa, the emergence of artemisinin resistance poses a serious threat to malaria control worldwide. Artemisinin resistance has been assessed primarily by means of the gene encoding the kelch protein (kelch13; PF3D7_1343700).
What is the standard treatment for falciparum malaria?
Artemisinin-based combination therapies (ACTs) are the recommended treatments for uncomplicated falciparum malaria. The following ACTs are recommended: – Artemether + lumefantrine; artesunate + amodiaquine; artesunate + mefloquine; artesunate + sulfadoxine-pyrimethamine, and dihydroartemisinin + piperaquine .
Is Artemisinin a quinine?
The efficacy of intravenous quinine, which is the mainstay for treating severe malaria in children, is decreasing in South East Asia and Africa. Artemisinin derivatives are a potential alternative to quinine. However, their efficacy compared to quinine in treating severe malaria in children is not clearly understood.
What are the drugs in artemisinin combination therapy?
Four ACTs are currently recommended by WHO: artesunate–mefloquine, artesunate–sulfadoxine–pyrimethamine (SP), artesunate–amodiaquine, and artemether–lumefantrine.
Which of the following are artemisinin derivatives used in malaria?
The four WHO-recommended oral artemisinin–based combination therapies (dihydroartemisinin–piperaquine, artemether–lumefantrine, artesunate–mefloquine, and artesunate–amodiaquine) have rapidly become first-line agents in the treatment of uncomplicated P. falciparum malaria in endemic countries.
What is the drug of choice for severe malaria?
For adults with severe malaria, artesunate should be the treatment of choice. The drug is more effective than quinine, is simple to administer, and is safe.
Is artemisinin an antibiotic?
Artemisinin has been widely used for the treatment of malaria for the past two decades [4]. Additionally, artemisinin is known to have antibacterial, antifungal, antileishmanial, antioxidant, antitumor, and anti-inflammatory activity [5,6,7].
