Is dermatofibrosarcoma protuberans malignant?
Is dermatofibrosarcoma protuberans malignant?
Dermatofibrosarcoma protuberans (DFSP) is a cutaneous malignancy that arises from the dermis and invades deeper tissue (eg, fat, fascia, muscle, bone). The cellular origin of DFSP is not clear. Evidence supports the cellular origin being fibroblastic, histiocytic, or neuroectodermal.
Does dermatofibrosarcoma protuberans metastasis?
Dermatofibrosarcoma protuberans (DFSP) is a tumor that develops in skin or subcutaneous tissue and is characterized by a protuberant growth pattern [1]. DFSP often recurs locally after surgery, but rarely metastasizes to distant sites and is classified as a sarcoma of intermediate-grade malignancy [2–7].
What is dermatofibrosarcoma protuberans?
Dermatofibrosarcoma protuberans (DFSP) is a very rare type of skin cancer that begins in connective tissue cells in the middle layer of your skin (dermis). Dermatofibrosarcoma protuberans may at first appear as a bruise or scar. As it grows, lumps of tissue (protuberans) may form near the surface of the skin.
Dermatofibrosarcoma protuberans, abbreviated DFSP, is a rare locally aggressive tumour of the skin . Destroys adnexal structures – somewhat unusual for a mostly benign tumour. Occasionally transforms to a (more aggressive) fibrosarcoma. Typically slow growing.
What is col6a3-pdgfd in dermatofibrosarcoma protuberans?
COL6A3-PDGFD is only rarely encountered in dermatofibrosarcoma protuberans; COL6A3-CSF1 is found in a subset of tenosynovial giant cell tumours; COL1A1-USP6 may be present in myositis ossificans, fibro-osseous pseudotumour of the digits and aneurysmal bone cyst.
What does CD34 positive mean in dermatofibrosarcoma?
C. Positive for Fontana-Masson & CD34. This is an example of pigmented dermatofibrosarcoma protuberans (Bednar tumor). The pigment is melanin which is positive with the Fontana-Masson stain, but not Prussian blue. The tumor cells are typically diffusely positive for CD34, but negative for Factor XIIIa.
What are the patterns of dermatofibroma on the face?
62 year old woman with unusual presentation of dermatofibroma on the face ( Clin Case Rep 2019;7:672 ) Patterns range from diffuse to reticular to hemangioma-like to keloid-like Spindled cells: thin, elongated nuclei with pointed ends and eosinophilic cytoplasm Histiocytic cells: epithelioid shaped cells with abundant pale cytoplasm
