How do you dilute dexmedetomidine?
How do you dilute dexmedetomidine?
Dexmedetomidine injection concentrate (100 mcg/mL) must be diluted in 0.9% sodium chloride solution to achieve the required concentration (4 mcg/mL) prior to administration. Add 2 mL (200 mcg) of dexmedetomidine to 48 mL of 0.9% sodium chloride for a total volume of 50 mL (4 mcg/mL).
What is dexmedetomidine HCl used for?
Precedex (dexmedetomidine hydrochloride) is an alpha2-adrenergic agonist with sedative properties used for short-term intravenous sedation.
How do you give precedex?
Precedex should be administered by continuous infusion not to exceed 24 hours. Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex prior to extubation.
What is a significant adverse effect related to the use of dexmedetomidine?
The adverse effects of dexmedetomidine include hypotension, hypertension, nausea, bradycardia, atrial fibrillation, and hypoxia (22, 28) (Figure 4). Overdose may cause first-degree or second-degree atrioventricular block.
How long does it take for dexmedetomidine to wear off?
Dexmedetomidine has a distribution half life of only 6 minutes and an elimination half life of 2 hours.
Can you Bolus dexmedetomidine?
Justification Dexmedetomidine given in a single peri-operative bolus without subsequent infusion has been shown to be beneficial. It would be arguably more practical to administer the dose as a rapid bolus. The hemodynamic effects of this have not been previously studied in healthy ASA I-II children (aged 5-10 years).
How do you draw up dexmedetomidine?
To prepare the infusion, withdraw 2 mL of Precedex and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL….Administration with Other Fluids
- 0.9% sodium chloride in water.
- 5% dextrose in water.
- 20% mannitol.
- Lactated Ringer’s solution.
- 100 mg/mL magnesium sulfate solution.
- 0.3% potassium chloride solution.
Can you give dexmedetomidine IV?
Dexmedetomidine Hydrochloride injections are available as Dexmedetomidine 50mcg/0.5ml, 100mcg/ml and 200mcg/2ml. It should be used in controlled intravenous device when being used via intravenous route. The dose should be individualized and titrated to the desired clinical effect.
Does dexmedetomidine cause respiratory depression?
Dexmedetomidine is safe to use in extubated spontaneous breathing intensive care patients and does not cause clinically significant respiratory depression.
How fast can you titrate precedex?
Precedex must be diluted in 0.9% sodium chloride solution to achieve required concentration (4 mcg/mL) prior to administration. Maintenance infusion: Start at 0.2 – 0.4 mcg/kg/hour and titrate to 0.1 – 0.2 mcg/kg/hour every 30 minutes to a maximum rate of 1.1 mcg/kg/hour.
What is dexdexmedetomidine hydrochloride?
Dexmedetomidine Hydrochloride is the hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities.
Is it necessary to discontinue Dexmedetomidine hydrochloride prior to extubation?
It is not necessary to discontinue dexmedetomidine hydrochloride in 0.9% sodium chloride injection prior to extubation. Dexmedetomidine hydrochloride in 0.9% sodium chloride injection is indicated for sedation of non-intubated patients prior to and/or during surgical and other procedures.
Is Dexmedetomidine hydrochloride compatible with diazepam?
Dexmedetomidine hydrochloride in 0.9% sodium chloride injection has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam. Compatibility studies have demonstrated the potential for absorption of dexmedetomidine hydrochloride in 0.9% sodium chloride injection to some types of natural rubber.
Can Dexmedetomidine hydrochloride be injected through a rubber gasket?
Although dexmedetomidine hydrochloride in 0.9% sodium chloride injection is dosed to effect, it is advisable to use administration components made with synthetic or coated natural rubber gaskets. Dexmedetomidine Hydrochloride in 0.9% Sodium Chloride Injection is clear and colorless and is available as follows.
