How does colchicine cause myopathy?

How does colchicine cause myopathy?

Myopathy has been reported as an important side effect of colchicine administration especially in patients with renal failure [1]. It is generally believed that colchicine-induced myopathy is associated with rather high creatine phosphokinase (CK) levels.

Does colchicine cause rhabdomyolysis?

In conclusion, colchicine, even at a low dose, can induce severe rhabdomyolysis. Renal transplant patients are often given colchicine for the treatment of gout as they are often taking azathioprine, which precludes the use of allopurinol, and because nephrotoxicity is a risk with nonsteroidal anti-inflammatory agents.

Can colchicine cause muscle damage?

Muscle damage warning: Colchicine can damage your muscles if you take it for 6 months or longer. Your risk is higher if you’re a senior. Taking other drugs that cause muscle damage, such as cholesterol medications, may increase this risk.

Can colchicine cause muscle weakness?

Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy. The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.

Does colchicine cause neuropathy?

The most common side effects of colchicine are nausea, vomiting and diarrhea. It may also cause, although more rarely, fatal multiple organ failure picture including hematologic, cardiac symptoms, neuropathy and myopathy (1).

Does colchicine cause nerve damage?

Colchicine has been in use for therapeutic purposes for many years. It can, however, cause subacute onset muscle and peripheral nerve toxicity in patients with chronic renal failure.

Can you have withdrawal from colchicine?

In this present meta-analysis, rates of patient withdrawal due to drug adverse effect occurred in 6.7-20% of included patients, though 4 of the 10 studies did not report the rate of patient withdrawal due to adverse effect. The most common adverse effect includes GI side effects such as nausea, vomiting, and diarrhea.

Is colchicine a neurotoxic?

As nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially nephrotoxic, colchicine is used frequently for both treatment and prevention of acute gout attack. Although colchicine is a relatively safe medication, it has been reported to be toxic.

Does colchicine cause peripheral neuropathy?

What is the pathophysiology of colchicine myoneuropathy?

Because of these features, colchicine myoneuropathy is usually misdiagnosed initially, either as probable polymyositis or as uremic neuropathy. The myopathy is vacuolar, marked by accumulation of lysosomes and autophagic vacuoles unrelated to necrosis or to the mild denervation in distal muscles.

Is colchicine myopathy associated with gout?

In this report we describe a characteristic syndrome of myopathy and neuropathy and present 12 new cases of the condition. Colchicine myopathy may occur in patients with gout who take customary doses of the drug but who have elevated plasma drug levels because of altered renal function.

What is the mechanism of cochicine toxicity?

Mechanisms of toxicity: Colchicine’s toxicity is an extension of its mechanism of action – binding to tubulin and disrupting the microtubular network.

What are the drug interactions with colchicine?

Drug interactions: CYP 3A4 and P-glycoprotein inhibitors, such as clarithromycin, erythromycin, ketoconazole, ciclosporin, and natural grapefruit juice can increase colchicine concentrations. Co-administration with statins may increase the risk of myopathy.