What drugs are inhibited by grapefruit juice?
What drugs are inhibited by grapefruit juice?
Through the inhibition of this enzyme system, grapefruit juice interacts with a variety of medications, leading to elevation of their serum concentrations. Most notable are its effects on cyclosporine, some 1,4-dihydropyridine calcium antagonists, and some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Why can’t you have grapefruit with statins?
Statins are medicines that lower your cholesterol. Grapefruit or grapefruit juice affects some statins. Do not drink grapefruit juice if you’re taking simvastatin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.
What medications should not be taken with grapefruit?
Examples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin).
Can I eat grapefruit in the morning and take Lipitor at night?
Grapefruit juice and certain statins (used to treat high cholesterol) such as Lipitor (atorvastatin), Mevacor (lovastatin), and Zocor (simvastatin) do not mix. Grapefruit juice inhibits a system of enzymes that helps break down dozens of medications, including Lipitor, Mevacor, and Zocor.
Which statin can you eat grapefruit with?
So, it’s safe to continue enjoying your grapefruit with pravastatin (Pravachol), rosuvastatin (Crestor), fluvastatin (Lescol), and pitavastatin (Livalo). If you love grapefruit or grapefruit juice and your provider recommends that you start taking a statin, one of these may be a good option for you.
Is grapefruit juice an inducer or inhibitor?
However, grapefruit juice contains psoralens which produce “suicide inhibition” of CYP3A4 (a reactive intermediate forms a covalent bond to irreversibly inactivate the enzyme). This causes large increases in blood levels of drugs that are metabolized by CYP3A4, notably lovastatin (see below data from [15]).
Can you eat grapefruit if you take cholesterol medicine?
Grapefruit contains a chemical that can interfere with your body’s ability to break down or metabolize certain statin medications. When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects.
What happens if you eat grapefruit while taking cholesterol medicine?
Some substances can interact with statins With some statins, drinking grapefruit juice, or eating grapefruit, is a bad idea. Grapefruit juice can cause that statin to stay in your body much longer, and the drug can build up. This can increase the risk of muscle breakdown, liver damage, and even kidney failure.
Why is grapefruit bad for medication?
Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
What happens when you mix grapefruit with medication?
Grapefruit doesn’t affect other statins because they are metabolized by a different enzyme, CYP2C9. Interestingly, the interaction between grapefruit and medications poses a danger only when taken orally. This is because the interaction happens in your digestive tract.
How does grapefruit interact with medication?
Grapefruit and grapefruit juice interact with a variety of medications through at least two distinct mechanisms. By inhibiting cytochrome enzymes, grapefruit allows higher-than-normal levels of some medications to enter your bloodstream.
Does grapefruit affect any medication?
, grapefruit might also affect your body if you’re taking allergy medication, such as fexofenadine (Allegra). Similar to how it affects certain statins, furanocoumarins in grapefruit can suppress the enzyme that helps your body process these medications. The compound hinders this enzyme, creating larger amounts of drugs in your bloodstream.
What medicines should I avoid with grapefruit?
Fexofenadine. It interferes with histamine,a substance in the body that causes sneezing,nasal congestion,itchy eyes and a runny nose.
