What is CD31 a marker for?

What is CD31 a marker for?

CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM-1), is thought to be a sensitive and specific marker for vascular differentiation. 1,2. It is a transmembrane glycoprotein expressed by endothelial cells and a variety of hematopoietic cells.

Does CD31 stain lymphatics?

We found D2-40 to be a sensitive and relatively specific marker for lymphatic endothelium in all parenchymatous organs. CD31, CD34, vWF, and Fli-1 did not discriminate between vascular and lymphatic EC and are therefore panvascular EC markers. However, other cells (including mesothelial cells) also stained for D2-40.

What cells express CD31?

PECAM-1 (CD31) is a 130 kDa glycoprotein expressed on endothelial cells, platelets and some leukocytes. CD31 is constitutively expressed on endothelial cells, and its expression is not increased by cytokines.

Do all endothelial cells express CD31?

CD31 is normally found on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, lymphocytes (T cells, B cells, and NK cells), megakaryocytes, and osteoclasts.

What is CD31 staining?

CD31 (cluster of differentiation 31) is expressed on endothelial cells, showing some membrane and occasional cytoplasmic staining. It is also expressed on megakaryocytes, histiocytes, plasma cells, and T-cell subsets.

Is CD31 an integrin?

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

Do macrophages express CD31?

For example, tumor-associated macrophages express CD31, which upon interaction with CD38 on cancer cells provide survival signals, particularly to chronic lymphocytic leukemia cells (37, 38).

Do T cells express CD31?

CD31 (PECAM-1) It is expressed on a variety of cell types, including T cells, mast cells, NK cells monocytes, granulocytes, endothelial cells, and platelets,36 and several binding partners have been described. Homophilic binding of CD31 by CD31 can mediate cellular adhesive contacts.

Are macrophages CD31 positive?

CD31-positive macrophages were identified in 48 of 59 (81%) cases. CD31-positive macrophages were present in 34 of 39 (87%) nonvascular tumors.

Why do we use immunohistochemical staining?

Immunohistochemistry is used to help diagnose diseases, such as cancer. It may also be used to help tell the difference between different types of cancer.

What is immunohistochemistry staining used for?

Immunohistochemical staining is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. Specific molecular markers are characteristic of particular cellular events such as proliferation or cell death (apoptosis).