What is Spherocytic anemia?

What is Spherocytic anemia?

Hereditary spherocytic anemia is a rare disorder of the surface layer (membrane) of red blood cells. It leads to red blood cells that are shaped like spheres, and premature breakdown of red blood cells (hemolytic anemia).

Is hemolytic anemia hereditary?

Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than they are made. Inherited hemolytic anemia means that parents pass the gene for the condition on to their children. Acquired hemolytic anemia is not something you are born with. You develop the condition later.

Is splenomegaly hereditary?

Enlargement of the spleen is called splenomegaly and can occur as a result of many infections, tumors, and hereditary or acquired conditions of the blood leading to hemolysis.

What part of the body is affected by sickle cell Anaemia?

Any and all major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints can suffer damage from the abnormal function of the sickle cells and their inability to flow through the small blood vessels correctly. Problems may include the following: Increased infections.

Does spherocytosis affect child?

The symptoms of spherocytosis are minor in some children. But for many children the condition is more serious. Your child may get these common symptoms of anemia: Pale skin, lips or nail beds compared to their normal color.

Can anemia run in families?

“Some people inherit genes that, one way or another, cause problems with the blood,” Dr. Murray says. Among the types of anemia that can be inherited are: Sickle-cell anemia.

Are you born with pernicious anemia?

Pernicious anemia is thought to be an autoimmune disorder, and certain people may have a genetic predisposition to this disorder. There is a rare congenital form of pernicious anemia in which babies are born lacking the ability to produce effective intrinsic factor.

Can HS cause anemia?

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and dermal tracts. We recently reported a high prevalence of anemia in HS patients.

Which blood disorder is hereditary?

Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells.

What causes hereditary nonspherocytic hemolytic anemia?

There may be as many as 16 red blood cell enzyme abnormalities that may cause hereditary nonspherocytic hemolytic anemia. In addition, HNSHA may arise as the result of immune disorders, toxic chemicals and drugs, antiviral agents (eg, ribavirin), physical damage, and infections.

How rare is nonpherocytic hemolytic anemia due to hexokinase deficiency?

Summary Summary. Nonspherocytic hemolytic anemia due to hexokinase deficiency (NSHA due to HK1 deficiency) is a very rare condition mainly characterized by severe, chronic hemolysis, beginning in infancy. Approximately 20 cases of this condition have been described to date.

Is splenectomy an effective treatment for hereditary hemolytic anemia?

However, splenectomy can have complications, and is not appropriate for all types of hereditary nonspherocytic hemolytic anemia. Stem cell therapy is currently being researched for multiple types of hereditary anemia. Stem cells are a type of “baseline” cell that can develop into any other type of cell in the body.

Is hemolytic anemia an autosomal recessive disorder?

When hereditary nonspherocytic hemolytic anemia is associated with defects in the membrane of red blood cells, or defects in a chemical step in the synthesis of hemoglobin from its component parts (porphyrin), or in the breakdown of sugars, the disorder is inherited as an autosomal recessive genetic trait.