What is drug induced interstitial nephritis?
What is drug induced interstitial nephritis?
Drug-induced acute interstitial nephritis (DI-AIN) is a drug hypersensitivity reaction (DHR) that manifests 7 to 10 days after exposure to the culprit drug. DHRs account for fewer than 15% of reported adverse drug reactions.
Does mesalamine affect the kidneys?
Asacol (mesalamine) is one of the safest drugs we have to treat ulcerative colitis. Very occasionally it makes diarrhea worse, and rarely does it cause some hair loss. Both of those adverse effects occur early, within a few weeks or months, and are reversible. Very rarely, Asacol can cause kidney and liver damage.
Which drugs cause acute interstitial nephritis?
Acute interstitial nephritis is an immune process that is most commonly caused by penicillins, diuretics, allopurinol, nonsteroidal anti-inflammatory drugs, cimetidine, and sulfonamides. Prompt recognition of the disease and cessation of the responsible drug are usually the only necessary therapy.
What is the meaning of acute interstitial nephritis?
Acute interstitial nephritis (AIN) is a renal lesion that typically causes a decline in kidney function and is characterized by an inflammatory infiltrate in the kidney interstitium [1]. It is most often induced by drug therapy.
Can omeprazole cause nephritis?
Omeprazole is a proton pump inhibitor that is used commonly in the treatment of acid-peptic disorders. Although omeprazole is generally well tolerated, serious adverse effects such as renal failure have been reported. Thus far, 17 cases of acute interstitial nephritis (AIN) secondary to omeprazole have been described.
What is the prognosis of mesalamine-induced nephritis?
Average time for mesalamine-induced interstitial nephritis is between 4 and 48 months after the initiation of drug. In 1 study of 151 adjudicated world-wide cases, 68% were males, nephrotoxicity occurred at a median age of 39.4 years, and the median time for development of renal injury after starting 5-ASA was 3.0 years. 17
Does mesalamine cause nephrotoxicity in Crohn disease?
Mesalamine-induced nephrotoxicity in the treatment of Crohn disease: a case study. These cases do not appear to be manifestations of hypersensitivity reactions as fever, eosinophilia, and skin rashes are usually not seen. These cases probably therefore represent a cell-mediated reaction.
What are the signs and symptoms of interstitial nephritis in Crohn disease?
Chronic interstitial nephritis is a rare occurrence in patients treated with these drugs for Crohn disease and ulcerative colitis. Patients often present with asymptomatic reductions in glomerular filtration rate, without accompanying pyuria, skin lesions, or eosinophilia, unlike cases of acute interstitial nephritis.
How common are renal-related adverse reactions to mesalamine?
Twenty-three percent of the adverse reactions to mesalamine were renal-related, which amounts to about 100 in a million prescriptions and no serious renal complications were reported for sulfasalazine.
