What is the pharmacologic action of spironolactone?

What is the pharmacologic action of spironolactone?

Mechanism of action: Aldactone (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.

How is spironolactone administered?

Spironolactone comes as a tablet and suspension (liquid; Carospir) to take by mouth. It usually is taken once or twice a day. Take spironolactone suspension consistently either with food or without food each time. Take spironolactone at around the same time(s) every day.

What does the nurse need to assess for when a patient is prescribed diuretics?

Nursing Considerations Assess patients for sulfa allergies, as some diuretics are sulfonamide derivatives. Monitor weight, intake, output, and serum electrolyte levels. Monitor blood glucose levels (some agents may cause hyperglycemia). Follow blood urea nitrogen and creatinine levels regularly.

What is the difference between furosemide and spironolactone?

Aldactone (spironolactone) Lasix (Furosemide) is a very effective water pill and it’ll certainly make you go to the bathroom more often. Removes extra water from your body. Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

What parameters should be monitored for patients on spironolactone?

(See Clinical Studies: Severe heart failure, and DOSAGE AND ADMINISTRATION: Severe heart failure.) ALDACTONE should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Can Spironolactone be given IV?

Aldactone given in a single dose i.v. to patients with CHF is a potent drug and can produce a dramatic response in some individuals who are refractory to routine therapy. The beneficial effects of Aldactone could be seen within the first 6 h especially in patients with secondary aldosteronism.

What should the nurse assess within an hour after administering a diuretic?

Adverse/Side Effects Patients who are taking thiazide diuretics should be monitored for electrolyte depletion, dehydration, weakness, hypotension, renal impairment, and hypersensitivities.

What are the Common side effects of spironolactone?

Spironolactone causes side effects that can range from minor ones like headaches to serious complications like stomach bleeding. Stomach bleeding with signs like bloody or tar black-colored stools, coughing up blood or vomit resembling ground-coffee High potassium levels.

Does spironolactone increase cancer risk?

Spironolactone, an aldosterone-antagonist, is associated with gynecomastia. Digoxin, which can also cause gynecomastia, has been associated with increased incidence of breast and uterus cancers. We therefore postulated that spironolactone use might also increase these cancer risks.

What is the most effective dosage of spironolactone to fight acne?

When using Aldactone as an acne treatment, the most common dosage is between 50 to 100 mg daily. Many dermatologists start off prescribing 25 mg and work up to the target dosage over the course of several weeks.

Is spironolactone a controlled substance?

Spironolactone is used in the treatment of edema; heart failure; high blood pressure; hirsutism; hypokalemia and belongs to the drug classes aldosterone receptor antagonists, potassium-sparing diuretics. Risk cannot be ruled out during pregnancy. Spironolactone 50 mg is not a controlled substance under the Controlled Substances Act (CSA).