What does the PTB domain bind to?
What does the PTB domain bind to?
Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine-dependent fashion to peptides that form a b turn. In these proteins, PTB domains play an important role in signal transduction by growth factor receptors.
Which of these protein motifs or domains bind to phospho tyrosine residues?
SH2 domains
SH2 domains bind to phosphotyrosine-containing peptides and control numerous signaling pathways involving tyrosine kinases[7].
Which domain recognizes phosphotyrosine?
Src homology 2 (SH2) domains mediate assembly of signaling complexes by binding specifically to tyrosine-phosphorylated proteins. A phosphotyrosine binding (PTB) domain has been identified which also binds specifically to tyrosine-phosphorylated targets, but is structurally different from SH2 domains.
What is PTB biology?
In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus.
What do SH2 domains do?
Src homology 2 (SH2) domains are protein modules (of approximately 100 amino acids) found in many proteins involved in tyrosine kinase signalling cascades. Their function is to bind tyrosine-phosphorylated sequences in specific protein targets.
What is SH1 domain?
The SH1 domain is the catalytic domain. The crystal structure of the Src-family tyrosine kinase hck has been solved [7]. Its catalytic (SH1) domain has an overall bilobal structure, with a small ATP-binding N-terminal lobe and a large peptide-binding C-terminal lobe.
What does SH2 domain do?
What is PDZ binding motif?
PDZ domains bind specific sequence motifs, usually found at the very C-terminus of proteins or, more rarely, at the end of β hairpin structures. PDZ domains bind their ligands, in a manner reminiscent of PTB domains, by incorporating them through hydrogen bonds as an extra strand in a β-sheet.
Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine-dependent fashion to peptides that form a β turn.
What does PTB stand for in biology?
P hospho t yrosine b inding ( PTB) domains are 100–150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. Additional N-terminal sequences are also required for high affinity binding and conferring specificity.
What is the phosphotyrosine binding domain of tensin?
In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus.
What are the x11/lin-10 proteins?
The X11/Lin-10 proteins are found in a complex with two other proteins, Lin-2 and Lin-7, which have also been implicated in basolateral targeting in worm epithelia. This protein complex is also likely to be important in the targeting of cell surface proteins in mammalian neurons and epithelia.
