What drug targets the renin-angiotensin-aldosterone system?

What drug targets the renin-angiotensin-aldosterone system?

Approved drugs that act on the RAAS that are discussed here include ACE inhibitors, AT1-receptor blockers (ARBs) and aldosterone-receptor antagonists (ARAs). These agents have been shown to be highly effective in lowering blood pressure and, particularly in the case of the ARBs, are extremely well tolerated.

What drugs affect the RAAS system?

There are well-established drugs that interfere with the renin-angiotensin-aldosterone system (RAAS) at several sites, including (1) angiotensin-converting enzyme inhibitors (ACEIs), (2) angiotensin II type I (AT 1) receptor blockers (ARBs), (3) direct renin inhibitors (DRIs), (4) mineralocorticoid receptor antagonists …

What is an RAS antagonist medication?

RAS antagonist medications include: Angiotensin II receptor blockers (ARBs) Angiotensin-converting enzyme (ACE) inhibitors. Direct renin inhibitors. Members qualify for the measure with the second fill, but the measurement period starts with the date of the first fill.

Which medication decreases every other product in the renin-angiotensin aldosterone system RAAS after renin?

ACE inhibitors (e.g., enalapril), angiotensin receptor blockers (ARBs, e.g., losartan), and aldosterone antagonists (e.g., spironolactone) all act to decrease the effect of the RAAS.

What four classes of antihypertensive drugs target the effects of renin?

Site of action of four classes of antihypertensive drugs that block the renin-angiotensin system: beta-blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and the direct renin inhibitor.

Which medication decreases every other product in the renin angiotensin aldosterone system RAAS after renin?

Is Amlodipine a RAS?

In particular, evidence suggests that fixed-dose perindopril/amlodipine effectively decreases BP and currently is the only RAS inhibitor/CCB combination proven to decrease all-cause and cardiovascular mortality as well as major cardiovascular events, and thus is a valuable option for the management of hypertension.

Is Lisinopril an angiotensin receptor blockers?

ACE inhibitors, or angiotensin-converting enzyme inhibitors, include lisinopril (Zestril), benazepril (Lotensin), and enalapril (Vasotec). ARBs, or angiotensin-receptor blockers, include losartan (Cozaar), valsartan (Diovan), and irbesartan (Avapro).

How do ACE inhibitors affect RAAS?

ACE inhibitors work by interfering with the body’s renin-angiotensin-aldosterone system (RAAS). RAAS is a complex system responsible for regulating the body’s blood pressure. The kidneys release an enzyme called renin in response to low blood volume, low salt (sodium) levels or high potassium levels.

Which of the following drugs is a direct renin inhibitor?

Aliskiren, the first oral direct renin inhibitor, received Food and Drug Administration approval for the treatment of hypertension in March 2007.

Which drug decreases renin release?

Those antihypertensive drugs that inhibit adrenergic nerve transmission tend therefore to lower plasma renin. beta-Adrenoreceptor blocking drugs also generally lower plasma renin by specific inhibition of renal renin release both in animals and humans. Diuretics and vasodilators in contrast elevate plasma renin levels.

Does amlodipine affect renin?

These findings suggest that inhibition of calcium channels by amlodipine stimulates renin secretion and renin gene expression in vivo. These stimulatory effects are almost additive to the changes of renin secretion occurring after an unilateral fall of renal perfusion pressure.

What are the two drugs that target the renin-angiotensin system?

Renin-angiotensin system blocking drugs The two major classes of drugs that target the RAS are the angiotensin-converting enzyme (ACE) inhibitors and the selective AT1 receptor blockers (ARBs). Although both of these drug classes target angiotensin II, the differences in their mechanisms of action have implications for their effects on ot …

Is direct inhibition of renin effective for the management of hypertension?

Direct inhibition of renin -the most proximal aspect of the RAS -became clinically feasible from 2007 with the introduction of aliskiren. This latter drug has been shown to be efficacious for the management of hypertension.

What are the two classes of drugs that target the Ras?

The two major classes of drugs that target the RAS are the angiotensin-converting enzyme (ACE) inhibitors and the selective AT1 receptor blockers (ARBs). Although both of these drug classes target angiotensin II, the differences in their mechanisms of action have implications for their effects on ot …