Can benzodiazepines cause rhabdomyolysis?
Can benzodiazepines cause rhabdomyolysis?
General anesthetic agents and overdosage with CNS depressants drugs, such as narcotics, cyclic antidepressants, benzodiazepines, antihistamines and barbiturates, cause rhabdomyolysis by pressure-induced ischemia due to prolonged immobilization.
Why do you give mannitol in rhabdomyolysis?
If urine output is inadequate, consider the use of diuretics such as mannitol (in adults) and furosemide. Mannitol, acting as an osmotic diuretic, is thought to increase urinary flow and reduce myoglobin cast obstruction in renal tubules.
What is the best treatment for rhabdomyolysis?
To treat rhabdomyolysis, your doctor will first give you fluids and electrolytes intravenously (through a vein). These IV fluids flush the toxins from your system. You may need to stay in the hospital for a few days. After treatment, physical therapy can help you strengthen your muscles after an initial period of rest.
What type of drugs cause rhabdomyolysis?
Which medications may cause rhabdomyolysis?
- Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors)
- Antihistamines (particularly in children)
- Salicylates.
- Caffeine.
- Fibric acid derivatives (eg, bezafibrate, clofibrate, fenofibrate, and gemfibrozil)
- Neuroleptics/antipsychotics.
What is drug induced rhabdomyolysis?
Rhabdomyolysis can result from direct muscle injury by myotoxic drugs, such as cocaine and alcohol. This mechanism must be distinguished from rhabdomyolysis that develops secondarily from muscle ischemia due to prolonged seizures or local muscle compression in comatose states following drug overdosage.
Is mannitol used for rhabdomyolysis?
However, many authors support the use of mannitol in rhabdomyolysis-induced renal failure, especially in crush injury victims as mannitol decreases osmotic swelling and edema in the injured muscle cells and helps restore the skeletal muscle function [22,23].
Which is the main electrolyte disturbance in rhabdomyolysis?
Electrolyte abnormalities are prominent features of rhabdomyolysis. Hyperphosphatemia, hyperkalemia, hypocalcemia (early), hypercalcemia (late) hyperuricemia, and hypoalbuminemia have been described. Hyperkalemia may be a result of both muscle injury and renal insufficiency or failure.
Why do I keep getting rhabdomyolysis?
The most common causes of single episodes of rhabdomyolysis are drugs, exercise and immobility. Defects in fatty acid β-oxidation are the most common metabolic myopathy to cause recurrent exercise-induced rhabdomyolysis.
How do I lower myoglobin levels?
Raising the pH of the urine to 6.5 or more can be facilitated by adding sodium bicarbonate to the fluids. Alkalinization of the urine has been postulated to minimize the breakdown of myoglobin into its nephrotoxic metabolites and to reduce crystallization of uric acid, thereby decreasing damage to tubule cells.
